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Curtis A Lockshin

from Lexington, MA
Age ~64
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Also known as:
Curtis M Lockshin, Curt A Lockshin
Phone and address:
7 Ross Rd, Lexington, MA 02173
(781) 863-2535
Related to:
Linus LockshinElana R Lockshin, 29
Connected to:
Gregory J Locksmith, 64Alan W Lockstedt, 68Steven Lockton, 46Bryan J Lockwald, 57Clemente Lockward, 53Mary H Lockwich, 77Abigail L Lockwood, 40Agnieszka Lockwood, 40Alisa I Lockwood, 74Alisia A Lockwood, 61

Curtis Lockshin Phones & Addresses

  • 7 Ross Rd, Lexington, MA 02173 (781) 863-2535
  • Hallandale Beach, FL
  • Hallandale, FL
  • Miami, FL
  • Cambridge, MA
  • Hollywood, FL
  • San Diego, CA
  • Somerville, MA

Resumes

Resumes

Curtis Lockshin Photo 1

Director At Chromadex

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Position:
VP, Corporate R&D Initiatives at OPKO Health, Inc., Director at ChromaDex, Director at Ruth K. Broad Biomedical Research Foundation
Location:
Irvine, California
Industry:
Biotechnology
Work:
OPKO Health, Inc. - Miami, FL since Oct 2011
VP, Corporate R&D Initiatives
ChromaDex - Irvine, CA since Apr 2011
Director
Ruth K. Broad Biomedical Research Foundation since Mar 2004
Director
Sorrento Therapeutics, Inc. - Greater San Diego Area Sep 2009 - Sep 2012
Director
Curtis Lockshin 2003 - 2011
Consultant, Biotechnology & Pharmaceuticals
Education:
Massachusetts Institute of Technology 1991 - 1998
PhD, Biological Chemistry Massachusetts Institute of Technology 1978 - 1986
S.B., Life Sciences
Curtis Lockshin Photo 2

Curtis Lockshin

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Business Records

Name / Title
Company / Classification
Phones & Addresses
Curtis Lockshin
Manager
Scivac USA, LLC
4400 Biscayne Blvd, Miami, FL 33137
Curtis Lockshin
Manager, CEO, Chairman
GUARDUM PHARMACEUTICALS LLC
200 Wheeler Rd, Burlington, MA 01803
4400 Biscayne Blvd, Miami, FL 33137
Curtis A. Lockshin
Director
RXi Pharmaceuticals Corporation
Biotechnology · A Development Stage Company Engaged In Biopharmaceutical Preparations · Biopharmaceutical Preparations · Mfg Pharmaceutical Preparations
257 Simarano Dr SUITE 101, Marlborough, MA 01752
1500 W Park Dr, Westboro, MA 01581
60 Prescott St, Worcester, MA 01605
(508) 767-3861
Curtis Lockshin
Director
Quikbyte Software, Inc
6042 Cornerstone Ct W, San Diego, CA 92121
5251 Dtc Pkwy, Englewood, CO 80111
4400 Biscayne Blvd, Miami, FL 33137

Publications

Us Patents

Stable Macroscopic Membranes Formed By Self-Assembly Of Amphiphilic Peptides And Uses Therefor

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US Patent:
6548630, Apr 15, 2003
Filed:
Jul 22, 1997
Appl. No.:
08/898300
Inventors:
Shuguang Zhang - Cambridge MA
Curtis Lockshin - Lexington MA
Alexander Rich - Cambridge MA
Todd Holmes - Cambridge MA
Assignee:
Massachusettes Insitute of Technology - Cambridge MA
International Classification:
C07K 700
US Classification:
530300, 530324, 530325, 530326, 530327, 530350, 514 12, 514 13, 514 14
Abstract:
Described herein is the self-assembly of amphiphilic peptides, i. e. , peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK) (ARARADAD) , were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimers disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin.

Stable Macroscopic Membranes Formed By Self-Assembly Of Amphiphilic Peptides And Uses Therefor

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US Patent:
6800481, Oct 5, 2004
Filed:
Mar 26, 1997
Appl. No.:
08/824513
Inventors:
Todd Holmes - Cambridge MA
Shuguang Zhang - Cambridge MA
Alexander Rich - Cambridge MA
C. Michael DiPersio - Norton MA
Curtis Lockshin - Lexington MA
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12N 502
US Classification:
435401, 435395
Abstract:
Described herein is the self-assembly of amphiphilic peptides, i. e. , peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK) (ARARADAD) , were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimers disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin.

Amines That Inhibit A Mammalian Anandamide Transporter, And Methods Of Use Thereof

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US Patent:
7049329, May 23, 2006
Filed:
May 15, 2003
Appl. No.:
10/439347
Inventors:
Brian M. Aquila - Marlborough MA, US
Seth C. Hopkins - Clinton MA, US
Curtis A. Lockshin - Lexington MA, US
Fengjiang Wang - Northborough MA, US
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K 31/135
A61K 31/34
A61K 31/44
C07D 307/04
US Classification:
514352, 546304, 549429, 564305, 514461, 514649
Abstract:
One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries.

Stable Macroscopic Membranes Formed By Self-Assembly Of Amphiphilic Peptides And Uses Therefor

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US Patent:
7098028, Aug 29, 2006
Filed:
Mar 17, 2003
Appl. No.:
10/390472
Inventors:
Todd Holmes - Cambridge MA, US
Shuguang Zhang - Cambridge MA, US
Alexander Rich - Cambridge MA, US
C. Michael DiPersio - Norton MA, US
Curtis Lockshin - Lexington MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C12N 5/02
C12N 5/00
C07K 7/06
US Classification:
435401, 435395, 435325, 530329
Abstract:
Described herein is the self-assembly of amphiphilic peptides, i. e. , peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)(ARARADAD), were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin.

Amines That Inhibit A Mammalian Anandamide Transporter, And Methods Of Use Thereof

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US Patent:
7511073, Mar 31, 2009
Filed:
May 23, 2006
Appl. No.:
11/439529
Inventors:
Brian M. Aquila - Marlborough MA, US
Seth C. Hopkins - Clinton MA, US
Curtis A. Lockshin - Lexington MA, US
Fengjiang Wang - Northborough MA, US
Assignee:
Sepracor, Inc. - Marlborough MA
International Classification:
A61K 31/34
A61K 31/135
C07D 307/04
C07C 211/03
US Classification:
514461, 514649, 549429, 564305
Abstract:
One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries.

Amines That Inhibit A Mammalian Anandamide Transporter, And Methods Of Use Thereof

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US Patent:
7671087, Mar 2, 2010
Filed:
Feb 25, 2009
Appl. No.:
12/392981
Inventors:
Brian M. Aquila - Marlborough MA, US
Seth C. Hopkins - Clinton MA, US
Curtis A. Lockshin - Lexington MA, US
Fengjiang Wang - Northborough MA, US
Assignee:
Sepracor Inc. - Marlborough MA
International Classification:
A61K 31/34
A61K 31/135
C07D 307/04
C07C 211/03
US Classification:
514461, 549429, 564305, 514649
Abstract:
One aspect of the present invention relates to amines. A second aspect of the present invention relates to the use of the amines as inhibitors of a mammalian anandamide transporter. The compounds of the present invention will also find use in the treatment of numerous ailments, conditions and diseases which afflict mammals, including but not limited to asthma, neuropathic pain, persistent pain, inflammatory pain, hyperactivity, hypertension, brain ischemia, Parkinson's disease, spasticity, Tourette's syndrome, schizophrenia, hemorrhagic shock, septic shock, cardiac shock, migrane, Horton's headache, multiple sclerosis, anorexia, AIDS wasting syndrome, organ rejection, autoimmune diseases, allergy, arthritis, Crohn's disease, malignant gliomas, neurodegenerative diseases, Huntington's chorea, glaucoma, nausea, anxiety, psychosis, attention deficit hyperactivity disorder, premature ejaculation, and stroke. Another aspect of the present invention relates to combinatorial libraries of amines, and methods for preparing the libraries.

Microstructured Optical Device For Remote Chemical Sensing

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US Patent:
7262856, Aug 28, 2007
Filed:
May 25, 2005
Appl. No.:
11/137701
Inventors:
Douglas S. Hobbs - Lexington MA, US
Curtis A. Lockshin - Lexington MA, US
James J. Cowan - Lexington MA, US
Robert B. Nilsen - Mystic CT, US
International Classification:
G01N 21/00
C12M 1/34
US Classification:
356436, 356440, 422 8205, 422 8209, 4352872, 4352887
Abstract:
A microstructure-based chemical sensor that can be interrogated by a remote observer. The device acts as an electromagnetic wave filter in the optical region of the spectrum, filtering one or more wavelength bands where the band spectral notch location shifts in response to the accumulation of material on the surface of the microstructure sensor. The apparatus has a substrate having a surface relief structure containing dielectric bodies with one or more physical dimensions smaller than the wavelength of the filtered electromagnetic waves, such structures repeated in an array covering at least a portion of the surface of the substrate. A retro-reflecting structure allows interrogation of the sensor over a wide field of view. The device is particularly useful as a water monitoring device in hard to reach locations, and as a chemical warfare or explosives detector that can be read from a safe distance.

Stable Macroscopic Membranes Formed By Self-Assembly Of Amphiphilic Peptides And Uses Therefor

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US Patent:
20070190603, Aug 16, 2007
Filed:
Aug 29, 2006
Appl. No.:
11/512753
Inventors:
Todd Holmes - Somerville MA, US
Shuguang Zhang - Cambridge MA, US
Alexander Rich - Cambridge MA, US
C. DiPersio - Norton MA, US
Curtis Lockshin - Lexington MA, US
International Classification:
C12P 21/06
C07H 21/04
C12N 5/08
C07K 14/47
US Classification:
435069100, 435366000, 435404000, 435320100, 536023200, 530350000
Abstract:
Described herein is the self-assembly of amphiphilic peptides, i.e., peptides with alternating hydrophobic and hydrophilic residues, into macroscopic membranes. The membrane-forming peptides are greater than 12 amino acids in length, and preferably at least 16 amino acids, are complementary and are structurally compatible. Specifically, two peptides, (AEAEAKAK)(ARARADAD), were shown to self-assemble into macroscopic membranes. Conditions under which the peptides self-assemble into macroscopic membranes and methods for producing the membranes are also described. The macroscopic membranes have several interesting properties: they are stable in aqueous solution, serum, and ethanol, are highly resistant to heat, alkaline and acidic pH, chemical denaturants, and proteolytic digestion, and are non-cytotoxic. The membranes are potentially useful in biomaterial applications such as slow-diffusion drug delivery systems, artificial skin, and separation matrices, and as experimental models for Alzheimer's disease and scrapie infection. The sequence of the peptide, EAK16, was derived from a putative Z-DNA binding protein from yeast, called zuotin. The cloning and characterization of the ZUO1 gene are also described.
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Curtis A Lockshin from Lexington, MA, age ~64 Get Report