Inventors:
Frank D. Lee - Chestnut Hill MA, US
Xun Meng - Newton MA, US
Noubar B. Afeyan - Lexington MA, US
Assignee:
Millipore Corporation - Billerica MA
International Classification:
G01N 33/53
Abstract:
Disclosed are methods for reliably detecting the presence of proteins, including proteins with various post-translational modifications (phosphorylation, glycosylation, methylation, acetylation, etc. ) in a sample by the use of one or more capture agents that recognize and interact with recognition sequences uniquely characteristic of a protein or a set of proteins (Proteome Epitope Tags, or PETs) in the sample. Arrays comprising these capture agents or PETs are also provided.