Dongfang F Meng

6603023, Aug 5, 2003

Feb 1, 2002

10/062376

Samuel J. Danishefsky - Englewood NJ
Peter Bertinato - Old Lyme CT
Dai-Shi Su - Ambler PA
DongFang Meng - New York NY
Ting-Chao Chou - Paramus NJ
Ted Kamenecka - New Brunswick NJ
Erik J. Sorensen - San Diego CA
Aaron Balog - New York NY
Kenneth A. Savin - Indianapolis IN
Scott Kuduk - Harleysville PA
Christina Harris - New York NY
Joseph R. Bertino - Branford CT

Sloan Kettering Institute for Cancer Research - New York NY

C07D31300

549346

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.

6800785, Oct 5, 2004

Oct 15, 2003

10/685719

Dongfang Meng - Westfield NJ

Merck Co., Inc. - Rahway NJ

C07C 4545

568322, 568315, 568326, 549416, 556436

The present invention relates to processes for the synthesis of intermediates useful for the synthesis of estrogen receptor modulators. The process includes new methods for annelating 5-, 6- and 7-membered cycloalkenones onto an indanone.

6965034, Nov 15, 2005

Dec 23, 2002

10/329090

Samuel J. Danishefsky - Englewood NJ, US
Peter Bertinato - Old Lyme CT, US
Dai-Shi Su - New York NY, US
DongFang Meng - New York NY, US
Ting-Chao Chou - Paramus NJ, US
Ted Kamenecka - New York NY, US
Erik J Sorensen - San Diego CA, US
Aaron Balog - New York NY, US
Kenneth A. Savin - New York NY, US
Scott Kuduk - Harleysville PA, US
Christina Harris - New York NY, US
Joseph R. Bertino - Branford CT, US

Sloan-Kettering Institute for Cancer Research - New York NY

C07D277/22
C07D303/02
C07D313/00

548203, 549271, 549448

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof, useful in the treatment of cancer and cancer which has developed a multidrug-resistant phenotype. Also provided are intermediates useful for preparing said epothilones.

6972335, Dec 6, 2005

Dec 4, 2001

10/004571

Samuel J. Danishefsky - Englewood NJ, US
Peter Bertinato - Old Lyme CT, US
Dai-Shi Su - New York NY, US
Dongfang Meng - New York NY, US
Ting-Chao Chou - Paramus NJ, US
Ted Kamenecka - New York NY, US
Erik J Sorensen - San Diego CA, US
Aaron Balog - New York NY, US
Kenneth A. Savin - New York NY, US

Sloan-Kettering Institute for Cancer Research - New York NY

C07D277/22

548202

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

7157604, Jan 2, 2007

Aug 9, 2002

10/486005

Dongfang Meng - Westfield NJ, US
Robert R. Wilkening - Maplewood NJ, US
Ronald W. Ratcliffe - Matawan NJ, US

Merck & Co., Inc. - Rahway NJ

C07C 211/45
C07C 233/15
C07C 233/25
C07C 233/33
C07D 307/46

564308, 564222, 549496, 514471, 514630, 514647

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

7432284, Oct 7, 2008

Sep 15, 2003

10/528008

Dann LeRoy Parker - Edison NJ, US
Robert R. Wilkening - Maplewood NJ, US
Dongfang Meng - Westfield NJ, US
Ronald W. Ratcliffe - Matawan NJ, US

Merck & Co., Inc. - Rahway NJ

A61K 31/445
A61K 31/122
C07D 211/06
C07C 49/115

514325, 546184, 546192, 546195, 546203, 546204, 549200, 549429, 568303, 568308, 568325, 568326, 514315, 514317, 514319, 514675, 514680

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Pagets disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.

7511152, Mar 31, 2009

Dec 5, 2005

11/792729

Mark L. Greenlee - Plainfield NJ, US
Dongfang Meng - Westfield NJ, US
Donald M. Sperbeck - East Hanover NJ, US
Kenneth J. Wildonger - Bridgewater NJ, US

Merck & Co., Inc. - Rahway NJ

C07D 249/16
C07D 403/00
C07D 249/04
A61K 31/41

548261, 548255, 548257, 548259, 514359

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, age-related mild cognitive impairment, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, irritable bowel syndrome, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.

7709508, May 4, 2010

Feb 12, 2009

12/378198

Mark L. Greenlee - Plainfield NJ, US
Dongfang Meng - Westfield NJ, US
Donald M. Sperbeck - East Hanover NJ, US
Kenneth J. Wildonger - Bridgewater NJ, US

Merck Sharp & Dohme - Rahway NJ

A61K 31/4192

514359

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, age-related mild cognitive impairment, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, irritable bowel syndrome, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.