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Wanli Te Bi

from San Ramon, CA
Age ~62

Wanli Bi Phones & Addresses

  • 402 Regal Lily Ln, San Ramon, CA 94583 (925) 648-1048
  • 49 Canyon Crest Ct, San Ramon, CA 94582
  • 623 Amberstone Ln, San Ramon, CA 94582
  • Raleigh, NC
  • Cincinnati, OH
  • 1810 San Carlos Ave, San Carlos, CA 94070 (650) 654-3608
  • 623 Amberstone Ln, San Ramon, CA 94582 (925) 648-1048

Work

Position: Protective Service Occupations

Education

Degree: Bachelor's degree or higher

Publications

Us Patents

Modified Oligonucleotides And Applications Thereof

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US Patent:
7517978, Apr 14, 2009
Filed:
Oct 12, 2005
Appl. No.:
11/250192
Inventors:
Khairuzzaman Bashar Mullah - Union City CA, US
Zhaochun Ma - San Carlos CA, US
Wanli Bi - San Ramon CA, US
Assignee:
Applied Biosystems, LLC - Foster City CA
International Classification:
C07H 21/04
C07H 21/02
C12Q 1/68
C12P 19/34
US Classification:
536 2433, 536 231, 536 243, 435 6, 435 911, 435 912
Abstract:
Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof.

Modified Oligonucleotides And Applications Thereof

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US Patent:
7943752, May 17, 2011
Filed:
Apr 14, 2009
Appl. No.:
12/423753
Inventors:
Khairuzzaman Bashar Mullah - Union City CA, US
Zhaochun Ma - San Carlos CA, US
Wanli Bi - San Ramon CA, US
Assignee:
Applied Biosystems, L.L.C. - Carlsbad CA
International Classification:
C07H 21/02
C07H 21/04
C12Q 1/68
C12P 19/34
US Classification:
536 231, 536 243, 536 2433, 435 6, 435 911, 435 912
Abstract:
Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof.

Nucleic Acid Amplification Using A Reversibly Modified Oligonucleotide

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US Patent:
8334099, Dec 18, 2012
Filed:
Jul 30, 2007
Appl. No.:
12/375100
Inventors:
Wanli Bi - San Ramon CA, US
International Classification:
C12Q 1/68
C07H 21/04
US Classification:
435 612, 536 2433
Abstract:
The present invention provides a method for amplification of a target nucleic acid sequence or signal, wherein an amplification reaction mixture is used which contains at least one reversibly modified oligonucleotide having a non-hydroxyl group 3′ end which can be converted into a hydroxyl 3′ end upon exposure to a chemical and/or irradiation and/or a range of temperature. The present invention also provides a reversibly modified oligonucleotide as described above, and a nucleic acid amplification reaction mixture and kit comprising such an oligonucleotide.

Modified Oligonucleotides And Applications Thereof

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US Patent:
8431366, Apr 30, 2013
Filed:
Mar 21, 2011
Appl. No.:
13/052382
Inventors:
Khairuzzaman Bashar Mullah - Union City CA, US
Zhaochun Ma - Sunnyvale CA, US
Wanli Bi - San Ramon CA, US
Assignee:
Applied Biosystems, LLC - Carlsbad CA
International Classification:
C12P 19/34
C12Q 1/68
C07H 21/00
C07H 21/02
US Classification:
435 911, 435 61, 435 912, 536 231, 536 243
Abstract:
Disclosed, among other things, are primers containing certain modified nucleobases in the 3′ terminal region of the primers that provide reduced formation of primer-dimers during amplification reactions, and various methods of use thereof.

Polynucleotide Sequence Assay

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US Patent:
20020150904, Oct 17, 2002
Filed:
Jul 3, 2001
Appl. No.:
09/898323
Inventors:
Wanli Bi - San Ramon CA, US
Kenneth Livak - San Jose CA, US
Will Bloch - White Salmon WA, US
International Classification:
C12Q001/68
C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
Disclosed are methods for detecting or quantifying one or more target polynucleotide sequences in a sample. In one aspect, a sample is contacted with first and second probe pair that are capable of hybridizing to a selected target sequence and a corresponding complementary sequence, respectively. Probe cleavage and ligation results in the formation of ligation products which can be generated in an exponential fashion when the target sequence and/or complement are present in the sample. In another embodiment, a single probe pair can be used to form ligation product in a linear fashion from a complementary template. Reagents and kits are also disclosed.

Polynucleotide Sequence Assay

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US Patent:
20040005585, Jan 8, 2004
Filed:
Jan 27, 2003
Appl. No.:
10/351955
Inventors:
Wanli Bi - San Ramon CA, US
Kenneth Livak - San Jose CA, US
Will Bloch - White Salmon WA, US
Assignee:
Applera Corporation - Foster City CA
International Classification:
C12Q001/68
C12P019/34
US Classification:
435/006000, 435/091200
Abstract:
Disclosed are methods for detecting or quantifying one or more target polynucleotide sequences in a sample. In one aspect, a sample is contacted with first and second probe pair that are capable of hybridizing to a selected target sequence and a corresponding complementary sequence, respectively. Probe cleavage and ligation results in the formation of ligation products which can be generated in an exponential fashion when the target sequence and/or complement are present in the sample. In another embodiment, a single probe pair can be used to form ligation product in a linear fashion from a complementary template. Reagents and kits are also disclosed.

Nucleic Acid Sequence Detection

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US Patent:
20040197801, Oct 7, 2004
Filed:
Nov 14, 2003
Appl. No.:
10/713479
Inventors:
Timothy Liu - Fremont CA, US
Scott Beavers - San Carlos CA, US
Wanli Bi - San Ramon CA, US
International Classification:
C12Q001/68
C12M001/34
US Classification:
435/006000, 435/287200
Abstract:
The present application discloses a system and a method for detecting a target nucleic acid sequence using a support comprising an electrode with a nucleic acid probe attached thereto. A nucleic acid target and a non-covalent photoelectrochemical label are contacted with the probe. The photoelectrochemical intercalator preferentially binds double-stranded nucleic acids. Irradiating the mixture generates a photocurrent at the electrode. Also disclosed is a support comprising an array of nucleic acid probe elements.

Concurrent Enzymatic Polynucleotide Synthesis And Detectable Signal Generation

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US Patent:
20050026166, Feb 3, 2005
Filed:
Dec 8, 2003
Appl. No.:
10/731214
Inventors:
Wanli Bi - San Ramon CA, US
International Classification:
C12Q001/68
C07H021/04
US Classification:
435006000, 536025320
Abstract:
The present invention is based, in part, on the discovery that structure specific nuclease, alone or in combination with nucleic acid polymerase, especially the ones lacking 5′ nuclease activity can be used for detection or measurement of target nucleic acid sequences. Accordingly the present invention provides methods and kits useful for generating signals indicative of the present of target nucleic acid sequences and for detection and/or measurement of target nucleic acid sequences.
Wanli Te Bi from San Ramon, CA, age ~62 Get Report