Inventors:
Jiachang Gong - Belle Mead NJ, US
Lisa J. Christopher - East Windsor NJ, US
Vinod Kumar Arora - Cheshire CT, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
A61K 31/706
A61P 35/00
A61K 31/53
C07D 487/04
C07H 15/26
US Classification:
514 25, 544183, 536 174, 514243
Abstract:
The present invention is directed to metabolites of (R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-ol, the compound of formula (I), pharmaceutical compositions thereof, and to methods of using the metabolites and the pharmaceutical compositions in the treatment of cancer.