Tsze Tsang Phones & Addresses
-
El Cerrito, CA
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Berkeley, CA
-
Rockville Centre, NY
-
Davis, CA
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Los Angeles, CA
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Reno, NV
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8367 Kent Dr, El Cerrito, CA 94530
Work
Position:
Production Occupations
Education
Degree:
Associate degree or higher
Emails
t***h@hotmail.com
Publications
Us Patents
Receptor-Type Kinase Modulators And Methods Of Use
View pageUS Patent:
7576074, Aug 18, 2009
Filed:
Jul 14, 2003
Appl. No.:
10/522004
Inventors:
Kenneth D. Rice - Mill Valley CA, US
Neel K. Anand - Burlingame CA, US
Joerg Bussenius - Foster City CA, US
Abigail R. Kennedy - San Leandro CA, US
Angie I. Kim - San Mateo CA, US
Csaba J. Peto - Alameda CA, US
Tsze H. Tsang - El Cerrito CA, US
Neel K. Anand - Burlingame CA, US
Joerg Bussenius - Foster City CA, US
Abigail R. Kennedy - San Leandro CA, US
Angie I. Kim - San Mateo CA, US
Csaba J. Peto - Alameda CA, US
Tsze H. Tsang - El Cerrito CA, US
International Classification:
A01N 43/00
A61K 31/33
A01N 43/54
A61K 31/517
C07D 401/00
C07D 403/00
C07D 413/00
C07D 417/00
C07D 419/00
C07D 239/72
A61K 31/33
A01N 43/54
A61K 31/517
C07D 401/00
C07D 403/00
C07D 413/00
C07D 417/00
C07D 419/00
C07D 239/72
US Classification:
514183, 5142662, 5142663, 5142664, 544284, 544287, 544293
Abstract:
The present invention provides compounds for modulating receptor kinase activity, particularly ephrin and EGFR, and methods of treating diseases mediated by receptor kinase activity utilizing the compounds and pharmaceutical compositions thereof. Diseases mediated by receptor kinase activity include, but are not limited to, diseases characterized in part by abnormal levels of cell proliferation (i. e. tumor growth), programmed cell death (apoptosis), cell migration and invasion and angiogenesis associated with tumor growth. Compounds of the invention include “spectrum selective” kinase modulators, compounds that inhibit, regulate and/or modulate signal transduction across subfamilies of receptor-type tyrosine kinases, including ephrin and EGFR.
Protein Kinase Modulators And Methods Of Use
View pageUS Patent:
7704995, Apr 27, 2010
Filed:
May 2, 2003
Appl. No.:
10/513081
Inventors:
Chris A. Buhr - Redwood City CA, US
Sunghoon Ma - Foster City CA, US
Zerom Tesfai - Castro Valley CA, US
Longcheng Wang - Palo Alto CA, US
Erick Wang Co - Redwood City CA, US
Sergey Epshteyn - Fremont CA, US
Abigail R Kennedy - San Leandro CA, US
Baili Chen - Palo Alto CA, US
Larisa Dubenko - San Francisco CA, US
Neel Kumar Anand - San Mateo CA, US
Tsze H. Tsang - El Cerrito CA, US
John M. Nuss - Danville CA, US
Csaba J Peto - Alameda CA, US
Kenneth D. Rice - Mill Valley CA, US
Mohamed Abdulkader Ibrahim - Mountain View CA, US
Kevin Luke Schnepp - Elk Grove CA, US
Xian Shi - San Francisco CA, US
James William Leahy - San Leandro CA, US
Jeff Chen - San Francisco CA, US
Lisa Esther Dalrymple - San Francisco CA, US
Timothy Patrick Forsyth - San Mateo CA, US
Tai Phat Huynh - Oakland CA, US
Grace Mann - Brisbane CA, US
Larry Wayne Mann - Redwood City CA, US
Craig Stacy Takeuchi - Burlingame CA, US
Peter Lamb - Oakland CA, US
David J. Matthews - San Francisco CA, US
Nicole Miller - San Francisco CA, US
Sunghoon Ma - Foster City CA, US
Zerom Tesfai - Castro Valley CA, US
Longcheng Wang - Palo Alto CA, US
Erick Wang Co - Redwood City CA, US
Sergey Epshteyn - Fremont CA, US
Abigail R Kennedy - San Leandro CA, US
Baili Chen - Palo Alto CA, US
Larisa Dubenko - San Francisco CA, US
Neel Kumar Anand - San Mateo CA, US
Tsze H. Tsang - El Cerrito CA, US
John M. Nuss - Danville CA, US
Csaba J Peto - Alameda CA, US
Kenneth D. Rice - Mill Valley CA, US
Mohamed Abdulkader Ibrahim - Mountain View CA, US
Kevin Luke Schnepp - Elk Grove CA, US
Xian Shi - San Francisco CA, US
James William Leahy - San Leandro CA, US
Jeff Chen - San Francisco CA, US
Lisa Esther Dalrymple - San Francisco CA, US
Timothy Patrick Forsyth - San Mateo CA, US
Tai Phat Huynh - Oakland CA, US
Grace Mann - Brisbane CA, US
Larry Wayne Mann - Redwood City CA, US
Craig Stacy Takeuchi - Burlingame CA, US
Peter Lamb - Oakland CA, US
David J. Matthews - San Francisco CA, US
Nicole Miller - San Francisco CA, US
Assignee:
Exelixis, Inc. - South San Francisco CA
International Classification:
C07D 279/16
C07D 279/12
C07D 417/12
C07D 265/36
C07D 413/12
C07D 403/12
C07D 401/12
C07D 405/12
C07D 409/12
C07D 411/12
C07D 419/12
C07D 241/18
C07D 241/20
A61K 31/55
A61K 31/497
A61K 31/5355
A61K 31/541
C07D 305/12
C07D 307/79
A61K 31/44
A61P 35/00
C07D 279/12
C07D 417/12
C07D 265/36
C07D 413/12
C07D 403/12
C07D 401/12
C07D 405/12
C07D 409/12
C07D 411/12
C07D 419/12
C07D 241/18
C07D 241/20
A61K 31/55
A61K 31/497
A61K 31/5355
A61K 31/541
C07D 305/12
C07D 307/79
A61K 31/44
A61P 35/00
US Classification:
51421705, 51425211, 51425213, 51425505, 51425506, 5142358, 5142278, 5142305, 514352, 544405, 544407, 544295, 544120, 544 586, 544 60, 544105, 540598, 549310, 546309, 546311
Abstract:
This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.
Azetidines As Mek Inhibitors For The Treatment Of Proliferative Diseases
View pageUS Patent:
7803839, Sep 28, 2010
Filed:
Oct 5, 2006
Appl. No.:
11/995928
Inventors:
Naing Aay - San Mateo CA, US
Neel Kumar Anand - Burlingame CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffry Kimo Curtis - San Anselmo CA, US
Steven Charles DeFina - Burlingame CA, US
Larisa Dubenko - San Francisco CA, US
Anagha Abhijit Joshi - Fremont CA, US
Abigail R. Kennedy - Oakland CA, US
Angie Inyoung Kim - San Mateo CA, US
Elena S. Koltun - Foster City CA, US
Jean-Claire Limun Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Neel Kumar Anand - Burlingame CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffry Kimo Curtis - San Anselmo CA, US
Steven Charles DeFina - Burlingame CA, US
Larisa Dubenko - San Francisco CA, US
Anagha Abhijit Joshi - Fremont CA, US
Abigail R. Kennedy - Oakland CA, US
Angie Inyoung Kim - San Mateo CA, US
Elena S. Koltun - Foster City CA, US
Jean-Claire Limun Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Assignee:
Exelixis, Inc. - South San Francisco CA
International Classification:
A61K 31/27
C07D 205/00
C07D 205/00
US Classification:
514477, 548950
Abstract:
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
Raf Modulators And Methods Of Use
View pageUS Patent:
7846959, Dec 7, 2010
Filed:
Mar 25, 2005
Appl. No.:
11/568789
Inventors:
Neel Kumar Anand - Burlingame CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffry Kimo Curtis - San Anselmo CA, US
Larisa Dubenko - San Francisco CA, US
Abigail R. Kennedy - Oakland CA, US
Steven Charles Defina - Burlingame CA, US
Angie I. Kim - San Mateo CA, US
Jean-Claire L. Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Anagha Abhijit Joshi - Fremont CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffry Kimo Curtis - San Anselmo CA, US
Larisa Dubenko - San Francisco CA, US
Abigail R. Kennedy - Oakland CA, US
Steven Charles Defina - Burlingame CA, US
Angie I. Kim - San Mateo CA, US
Jean-Claire L. Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Anagha Abhijit Joshi - Fremont CA, US
Assignee:
Exelixis, Inc. - South San Francisco CA
International Classification:
C07D 231/02
US Classification:
514405, 514403, 548356, 5483601, 5483611
Abstract:
The present invention relates to compounds of the Formula I, wherein G, A, X1, X2, X3, Z, E, Y, and X are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Raf. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.
Anaplastic Lymphoma Kinase Modulators And Methods Of Use
View pageUS Patent:
7872014, Jan 18, 2011
Filed:
Jul 23, 2004
Appl. No.:
10/565657
Inventors:
Neel Kumar Anand - Burlingame CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffry Kimo Curtis - San Anselmo CA, US
Larisa Dubenko - San Francisco CA, US
Abigail R. Kennedy - Oakland CA, US
Richard G. Khoury - Redwood City CA, US
Angie I. Kim - San Mateo CA, US
Jean-Claire L. Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffry Kimo Curtis - San Anselmo CA, US
Larisa Dubenko - San Francisco CA, US
Abigail R. Kennedy - Oakland CA, US
Richard G. Khoury - Redwood City CA, US
Angie I. Kim - San Mateo CA, US
Jean-Claire L. Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Assignee:
Exelixis, Inc. - South San Francisco CA
International Classification:
C07D 471/02
A61K 31/4745
A61K 31/4745
US Classification:
514291, 514292, 546 82
Abstract:
The present invention comprises compounds and pharmaceutical compositions comprising the compounds that are inhibitors of ALK. The invention also comprises methods of using the compounds and compositions to treat diseases mediated by ALK, including diseases such as cancer, immunological disorders, cardiovascular diseases, and other degenerative disorders.
Azetidines As Mek Inhibitors For The Treatment Of Proliferative Diseases
View pageUS Patent:
7915250, Mar 29, 2011
Filed:
May 5, 2010
Appl. No.:
12/774544
Inventors:
Naing Aay - San Mateo CA, US
Neel Kumar Anand - Burlingame CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffry Kimo Curtis - San Anselmo CA, US
Steven Charles DeFina - Burlingame CA, US
Larisa Dubenko - San Francisco CA, US
Anagha Abhijit Joshi - Fremont CA, US
Abigail R. Kennedy - Oakland CA, US
Angie Inyoung Kim - San Mateo CA, US
Elena S. Koltun - Foster City CA, US
Jean-Claire Limun Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Neel Kumar Anand - Burlingame CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffry Kimo Curtis - San Anselmo CA, US
Steven Charles DeFina - Burlingame CA, US
Larisa Dubenko - San Francisco CA, US
Anagha Abhijit Joshi - Fremont CA, US
Abigail R. Kennedy - Oakland CA, US
Angie Inyoung Kim - San Mateo CA, US
Elena S. Koltun - Foster City CA, US
Jean-Claire Limun Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Assignee:
Exelixis, Inc. - South San Francisco CA
International Classification:
A61K 31/397
A61K 31/50
A61K 31/505
A61K 31/4523
A61K 31/4178
A61K 31/50
A61K 31/505
A61K 31/4523
A61K 31/4178
US Classification:
51421018, 514248, 51425203, 51425205, 514256, 514318, 514403, 544235, 544242, 544333, 544405, 546208, 546210, 5462681, 5462684, 5462754
Abstract:
Disclosed are compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof. Such compounds are MEK inhibitors and are useful in the treatment of proliferative diseases, such as cancer. Also disclosed are pharmaceutical compositions containing such compounds as well as methods of using the compounds and compositions of the invention in the treatment of cancer.
Tropane Compounds
View pageUS Patent:
8012956, Sep 6, 2011
Filed:
Oct 27, 2008
Appl. No.:
12/290159
Inventors:
Kenneth D. Rice - San Rafael CA, US
Naing Aay - San Mateo CA, US
Neel Kumar Anand - Burlingame CA, US
Arlyn Arcalas - South San Francisco CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Chris A. Buhr - Redwood City CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffrey Kimo Curtis - San Anselmo CA, US
Steven Charles Defina - Burlingame CA, US
Larisa Dubenko - San Francisco CA, US
Abigail R. Kennedy - Oakland CA, US
Angie Inyoung Kim - San Mateo CA, US
Katherine Lara - San Mateo CA, US
Sunghoon Ma - Foster City CA, US
Jean-Claire Limun Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Tsze H. Tsang - El Cerrito CA, US
Longcheng Wang - Palo Alto CA, US
Naing Aay - San Mateo CA, US
Neel Kumar Anand - Burlingame CA, US
Arlyn Arcalas - South San Francisco CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Chris A. Buhr - Redwood City CA, US
Joerg Bussenius - Foster City CA, US
Simona Costanzo - Los Altos CA, US
Jeffrey Kimo Curtis - San Anselmo CA, US
Steven Charles Defina - Burlingame CA, US
Larisa Dubenko - San Francisco CA, US
Abigail R. Kennedy - Oakland CA, US
Angie Inyoung Kim - San Mateo CA, US
Katherine Lara - San Mateo CA, US
Sunghoon Ma - Foster City CA, US
Jean-Claire Limun Manalo - Daly City CA, US
Csaba J. Peto - Alameda CA, US
Tsze H. Tsang - El Cerrito CA, US
Longcheng Wang - Palo Alto CA, US
Assignee:
Exelixis, Inc. - South San Francisco CA
International Classification:
A61K 31/46
A61K 31/5377
A61K 31/496
A61K 31/497
C07D 451/04
A61K 31/5377
A61K 31/496
A61K 31/497
C07D 451/04
US Classification:
51421021, 5142332, 51425304, 51425505, 514304, 546124, 546125, 544127, 544362, 544405
Abstract:
A compound according to Formula I or II:.
Kinase Modulators And Methods Of Use
View pageUS Patent:
8076338, Dec 13, 2011
Filed:
Apr 22, 2005
Appl. No.:
11/568173
Inventors:
Neel K. Anand - Burlingame CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Lynne Canne Bannen - Pacifica CA, US
Diva Sze-Ming Chan - San Francisco CA, US
Baili Chen - Palo Alto CA, US
Erick Wang Co - San Diego CA, US
Simona Costanzo - Los Altos CA, US
Steven Charles Defina - Burlingame CA, US
Larisa Dubenko - San Francisco CA, US
Maurizio Franzini - San Francisco CA, US
Ping Huang - Mountain View CA, US
Vasu Jammalamadaka - Pleasonton CA, US
Richard George Khoury - Redwood City CA, US
Moon Hwan Kim - Palo Alto CA, US
Rhett Ronald Klein - Chicago IL, US
Donna Tra Le - San Jose CA, US
Morrison B. Mac - San Francisco CA, US
John M. Nuss - Danville CA, US
Jason Jevious Parks - Sacramento CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Amy Lew Tsuhako - Milpitas CA, US
Yong Wang - Foster City CA, US
Wei Xu - Danville CA, US
Charles M. Blazey - San Francisco CA, US
Owen Joseph Bowles - Pacifica CA, US
Joerg Bussenius - Foster City CA, US
Lynne Canne Bannen - Pacifica CA, US
Diva Sze-Ming Chan - San Francisco CA, US
Baili Chen - Palo Alto CA, US
Erick Wang Co - San Diego CA, US
Simona Costanzo - Los Altos CA, US
Steven Charles Defina - Burlingame CA, US
Larisa Dubenko - San Francisco CA, US
Maurizio Franzini - San Francisco CA, US
Ping Huang - Mountain View CA, US
Vasu Jammalamadaka - Pleasonton CA, US
Richard George Khoury - Redwood City CA, US
Moon Hwan Kim - Palo Alto CA, US
Rhett Ronald Klein - Chicago IL, US
Donna Tra Le - San Jose CA, US
Morrison B. Mac - San Francisco CA, US
John M. Nuss - Danville CA, US
Jason Jevious Parks - Sacramento CA, US
Kenneth D. Rice - San Rafael CA, US
Tsze H. Tsang - El Cerrito CA, US
Amy Lew Tsuhako - Milpitas CA, US
Yong Wang - Foster City CA, US
Wei Xu - Danville CA, US
Assignee:
Exelixis, Inc. - South San Francisco CA
International Classification:
A61K 31/501
A61K 31/497
C07D 473/16
C07D 401/04
A61K 31/497
C07D 473/16
C07D 401/04
US Classification:
51425202, 51425216, 544277, 544238, 544363
Abstract:
The present invention relates to compounds of the Formula (I) and (II) wherein R, R, R-R, m, n, X-X, and Qare defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.