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Toohyon S Cho

from Houston, TX
Age ~74
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Also known as:
Too Hyon Cho, Toohyon Hyon Chotoo, Hyon Cho Too, Hyon Cho Toohyon, Yon Cho Toohyon, M Cho
Phone and address:
970 Bunker Hill Rd, Houston, TX 77024
Related to:
Johanna N Cho
Connected to:
Abraham Cho, 47Aesop Cho, 67Ah M Cho, 77Alan Cho, 44Albert W Cho, 58Ali S Cho, 34Andre T Cho, 44Angie E Cho, 43Anna Cho, 60Annabel K Cho, 39

Toohyon Cho Phones & Addresses

  • 970 Bunker Hill Rd, Houston, TX 77024
  • Philadelphia, PA
  • Westborough, MA
  • Weston, FL
  • Hopkinton, MA
  • 1451 Springrock Ln APT B, Houston, TX 77055

Publications

Us Patents

Purified Adenoviral Compositions

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US Patent:
6726907, Apr 27, 2004
Filed:
Apr 24, 2000
Appl. No.:
09/556570
Inventors:
Shuyuan Zhang - Sugar Land TX
Capucine Thwin - Seattle WA
Zheng Wu - Sugarland TX
Toohyon Cho - Philadelphia PA
Deborah R. Wilson - Houston TX
Lucetta Caston - Limerick PA
Assignee:
Introgen Therapeutics, Inc. - Austin TX
International Classification:
C12N 700
US Classification:
424 932, 4242331, 4241991, 424 936, 4352351, 4353201, 435239
Abstract:
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production witrh cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

Method For The Production And Purification Of Adenoviral Vectors

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US Patent:
7125706, Oct 24, 2006
Filed:
Jun 12, 2001
Appl. No.:
09/880609
Inventors:
Shuyuan Zhang - Sugar Land TX, US
Capucine Thwin - Spring TX, US
Zheng Wu - Sugar Land TX, US
Toohyon Cho - Houston TX, US
Shawn Gallagher - Missouri City TX, US
Assignee:
Introgen Therapeutics, Inc. - Houston TX
International Classification:
C12N 7/01
C12N 15/861
A61K 39/235
US Classification:
4352351, 435239, 4353201, 4241991, 4242331, 424 932
Abstract:
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

Method For The Production And Purification Of Adenoviral Vectors

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US Patent:
7445930, Nov 4, 2008
Filed:
Jul 30, 2004
Appl. No.:
10/909066
Inventors:
Shuyuan Zhang - Sugarland TX, US
Capucine Thwin - Seattle WA, US
Zheng Wu - Sugarland TX, US
Toohyon Cho - Philadelphia PA, US
Deborah Wilson - Houston TX, US
Lucetta Caston - Limerick PA, US
Assignee:
Introgen Therapeutics Inc. - Austin TX
International Classification:
C12N 15/00
A61K 39/00
A61K 39/23
A61K 39/095
US Classification:
4353201, 4241841, 4242331
Abstract:
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production witrh cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

Methods For Producing Purified Adenoviral Vectors

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US Patent:
7510875, Mar 31, 2009
Filed:
Dec 27, 2001
Appl. No.:
10/033571
Inventors:
Shuyuan Zhang - Sugarland TX, US
Capucine Thwin - Seattle WA, US
Zheng Wu - Sugarland TX, US
Toohyon Cho - Philadelphia PA, US
Deborah Wilson - Houston TX, US
Lucetta Caston - Limerick PA, US
Assignee:
Introgen Therapuetics, Inc. - Austin TX
International Classification:
C12N 7/02
C12N 5/00
A61K 39/235
C07K 1/00
A23J 1/00
US Classification:
435329, 4242331, 435383, 530417
Abstract:
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

Method For The Production And Purification Of Adenoviral Vectors

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US Patent:
7732129, Jun 8, 2010
Filed:
Dec 1, 1998
Appl. No.:
09/203078
Inventors:
Shuyuan Zhang - Sugar Land TX, US
Capucine Thwin - Spring TX, US
Zheng Wu - Sugar Land TX, US
Toohyon Cho - Houston TX, US
Shawn Gallagher - Missouri City TX, US
Assignee:
Crucell Holland B.V. - Leiden
International Classification:
C12Q 1/70
US Classification:
435 5
Abstract:
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

Methods For Treating Patients With Adenoviral Vectors

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US Patent:
20030008375, Jan 9, 2003
Filed:
Dec 27, 2001
Appl. No.:
10/033491
Inventors:
Shuyuan Zhang - Sugar Land TX, US
Capucine Thwin - Spring TX, US
Zheng Wu - Sugar Land TX, US
Toohyon Cho - Houston TX, US
Assignee:
Introgen Therapeutics, Inc.
International Classification:
C12N007/00
C12N007/02
C12N015/861
US Classification:
435/235100, 435/456000, 435/239000
Abstract:
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production witrh cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

Method For The Production And Purification Of Adenoviral Vectors

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US Patent:
20070155008, Jul 5, 2007
Filed:
Aug 23, 2006
Appl. No.:
11/508780
Inventors:
Shuyuan Zhang - Sugar Land TX, US
Capucine Thwin - Sugar Land TX, US
Zheng Wu - Sugar Land TX, US
Toohyon Cho - Houston TX, US
Deborah Wilson - Houston TX, US
Lucetta Caston - Limerick PA, US
Assignee:
INTROGEN THERAPEUTICS INC. - Austin TX
International Classification:
C12P 21/06
C12N 15/00
US Classification:
435320100, 435069100
Abstract:
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.

Method For The Production And Purification Of Retroviral Vectors

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US Patent:
20100055763, Mar 4, 2010
Filed:
Oct 2, 2009
Appl. No.:
12/572943
Inventors:
SHUYUAN ZHANG - Sugar Land TX, US
Capucine Thwin - Spring TX, US
Zheng Wu - Sugar Land TX, US
Toohyon Cho - Houston TX, US
International Classification:
C12N 7/02
US Classification:
435239
Abstract:
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of yields is the use of detergent lysis. Combination of these aspects of the invention permits purification of virus by a single chromatography step that results in purified virus of the same quality as preparations from double CsCl banding using an ultracentrifuge.
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Toohyon S Cho from Houston, TX, age ~74 Get Report