Inventors:
Kiyoshi Nakayama - Funabashi, JP
Masami Ohtsuka - Tokyo, JP
Haruko Kawato - Tokyo, JP
William Watkins - Sunnyvale CA, US
Jason Zhang - Foster City CA, US
Monica Palme - San Jose CA, US
Aesop Cho - Mountain View CA, US
Assignee:
Daiichi Pharmaceutical Co., Ltd. - Tokyo
Trine Pharmaceuticals, Inc. - Waltham MA
International Classification:
C07D 417/06
C07D 417/12
A61K 31/427
US Classification:
5142332, 514248, 514258, 514300, 514312, 544116, 544235, 544236, 544282, 546122, 546153, 546155, 546156
Abstract:
A medicament for preventive and/or therapeutic treatment of a microbial infection which comprises as an active ingredient a compound represented by the following general formula (I): wherein, Rand Rrepresent hydrogen atom, a halogen atom, hydroxyl group or the like, Wrepresents —CH═CH—, —CHO—, —CHCH— or the like; Rrepresents hydrogen atom, a halogen atom, hydroxyl group or an amino group; Rrepresents hydrogen atom, a group of —OZR(Zrepresents an alkylene group, a fluorine-substituted alkylene group or a single bond, and Rrepresents a cyclic alkyl group, an aryl group or the like); Wrepresents a single bond or —C(R)═C(R)— (Rand Rrepresent hydrogen atom, a halogen atom, a lower alkyl group or the like, Q represents an acidic group, but Wand Q may together form vinylidenethiazolidinedione or an equivalent heterocyclic ring; m and n represent an integer of 0 to 2, and q represents an integer of 0 to 3.