US Patent:
20220259669, Aug 18, 2022
Inventors:
- Princeton NJ, US
Lan ZHANG - Princeton NJ, US
Keyur H. DESAI - Princeton NJ, US
Neeraj ADYA - Princeton NJ, US
Zhenhao QI - Princeton NJ, US
Alex GREENFIELD - Princeton NJ, US
George C. LEE - Princeton NJ, US
Scott Adams ELY - Princeton NJ, US
Saumya PANT - Princeton NJ, US
George A. GREEN - Newton NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12Q 1/6886
C07K 16/28
G01N 33/68
Abstract:
The present disclosure provides methods of identifying a subject suitable for an immunooncology (I-O) therapy comprising measuring the expression of one or more of STAT1, IFNγ, NECTIN2, and CSFIR. In some aspects, the I-O therapy comprises administering an anti-PD-1 antibody or antigen-binding portion thereof or an anti-PD-L1 antibody or antigen-binding portion thereof to the subject.