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Rohini Muthuswami Phones & Addresses

  • 820 Dexter St, Denver, CO 80220 (303) 393-9764
  • 122 Oakhurst Cir, Charlottesville, VA 22903 (804) 296-9045
  • Alden, IL

Publications

Us Patents

Polynucleotides Encoding Mammalian Dna-Dependent Atpase A Polypeptides

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US Patent:
6531306, Mar 11, 2003
Filed:
Nov 28, 2000
Appl. No.:
09/722825
Inventors:
Joel W. Hockensmith - Charlottesville VA
Rohini Muthuswami - Denver CO
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
C12N 916
US Classification:
435196, 4352523, 4352544, 4353201, 435325, 435366, 536 232
Abstract:
Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.

Mammalian Dna-Dependent Atpase A Polypeptides And Fusions Thereof

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US Patent:
6537791, Mar 25, 2003
Filed:
Nov 28, 2000
Appl. No.:
09/722487
Inventors:
Joel W. Hockensmith - Charlottesville VA
Rohini Muthuswami - Denver CO
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
C12N 916
US Classification:
435196, 435195, 536 232, 536 234
Abstract:
Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.

Methods And Compositions For Targeting Dna Metabolic Processes Using Aminoglycoside Derivatives

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US Patent:
6573060, Jun 3, 2003
Filed:
Nov 28, 2000
Appl. No.:
09/722708
Inventors:
Joel W. Hockensmith - Charlottesville VA
Rohini Muthuswami - Denver CO
Assignee:
University of Virginia Patent Foundation - Charlottesville VA
International Classification:
C12Q 148
US Classification:
435 15, 435 18, 536 41, 536 132, 536 133, 536 136, 536 137
Abstract:
Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.

Methods And Compositions For Targeting Dna Metabolic Processes Using Aminoglycoside Derivatives

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US Patent:
61806129, Jan 30, 2001
Filed:
Oct 27, 1998
Appl. No.:
9/179558
Inventors:
Joel W. Hockensmith - Charlottesville VA
Rohini Muthuswami - Denver CO
Assignee:
The University of Virginia Patent Foundation - Charolottesville VA
International Classification:
A01N 4304
US Classification:
514 25
Abstract:
Protein targets for disease intervention through inhibition of nucleic acid metabolism are disclosed. Novel polypeptides for one such target, DNA-dependent ATPase A, and novel polynucleotides encoding DNA-dependent ATPase A are disclosed. Phosphoaminoglycoside compounds which act on such protein targets to inhibit nucleic acid metabolism. In addition, screening assays for identifying compounds that inhibit nucleic acid-dependent ATPase activity, including, but not limited to, DNA-dependent ATPase A, are disclosed. Such compounds are useful in the treatment of diseases, including but not limited to cancer and infectious disease, through disruption of nucleic acid metabolism and induction of apoptosis. Moreover, methods for prevention and treatment of diseases including, but not limited to cancer and infectious disease are disclosed.
Rohini Muthuswami from Denver, CO, age ~53 Get Report