Inventors:
Paul A. Negulescu - Del Mar CA, US
Alec T. Harootunian - San Diego CA, US
Philip E. Salzmann - Cardiff CA, US
Javier H. Flores - San Diego CA, US
James E. Sinclair - Carlsbad CA, US
Minh Vuong - San Diego CA, US
Ashvani K. Singh - San Diego CA, US
Fred F. VanGoor - San Diego CA, US
Assignee:
Vertex Pharmaceutcals, Inc. - Cambridge MA
International Classification:
C12N 5/00
US Classification:
435395, 4352971, 4352975, 4352884, 2044036
Abstract:
A device for characterizing the biological properties of cells can include a plurality of dual-compartment assay chambers wherein the compartments of each chamber are separated by a cell layer across which ions can flow. The biological properties of the cell layer in the presence or absence of experimental compounds can be determined by measuring an electrical gradient across the layer. A individual dual-compartment chamber of this type may be referred to as an “Ussing chamber. ”.