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Paul M Skonezny

from Baldwinsville, NY
Age ~73
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Related to:
Earl P KinvilleAnnmarie M Mlynch, 53Joy M Doan, 48Edith L Skonezny, 100Brian M Kinville, 50Dawn M Kinville, 50Darlene E Skonezny, 73Marcel E SkoneznyMary C SkoneznyCraig J Doan, 49
Connected to:
Paul M Skonezny, 73Steven J Skonicki, 45David A Skonieczny, 71Kenneth F Skonieczny, 69Krzysztof Skonieczny, 44Maria A Skonieczny, 97Patrick T Skonie, 43Ronald M Skonieczny, 64Sarah Skonieczny, 66Stephen Skonieczny, 54

Paul Skonezny Phones & Addresses

  • 3471 Van Wie Dr, Baldwinsville, NY 13027 (315) 720-1975
  • Lysander, NY
  • Clermont, FL
  • Syracuse, NY
  • 6151 Wynmoor Dr, Cicero, NY 13039
  • Durham, NC
  • Clay, NY
  • Blasdell, NY

Publications

Us Patents

Enzymatic Resolution Of Aryl And Thio-Substituted Acids

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US Patent:
6620600, Sep 16, 2003
Filed:
Sep 5, 2001
Appl. No.:
09/946722
Inventors:
Jingyang Zhu - Jamesville NY
Li You - Jamesville NY
Brenda J. White - Jamesville NY
Shannon X. Zhao - East Syracuse NY
Paul M. Skonezny - Cicero NY
Assignee:
Bristol-Myers Squibb Co. - Princeton NJ
International Classification:
C12P 1100
US Classification:
435130, 435136, 435197
Abstract:
Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is C or C aromatic group that can be substituted with H, C to C alkyl, trifluoromethyl or halo, R is halo or âSâR , wherein R is H or acetyl, and R is H or C to C alkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby R is C to C alkyl with a lipase derived from to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase (which can be buffered).

Enzymatic Resolution Of Aryl And Thio-Substituted Acids

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US Patent:
7026143, Apr 11, 2006
Filed:
Jul 23, 2003
Appl. No.:
10/625404
Inventors:
Jingyang Zhu - Jamesville NY, US
Li You - Jamesville NY, US
Brenda J. White - Jamesville NY, US
Shannon X. Zha - East Syracuse NY, US
Paul M. Skonezny - Cicero NY, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12P 11/00
US Classification:
435130, 435195, 435197
Abstract:
Provided is a method of resolving a racemic mixture of a compound of formula I to obtain a desired enantiomer: wherein Ar is Cor Caromatic group that can be substituted with H, Cto Calkyl, trifluoromethyl or halo, Ris halo or —S—R, wherein Ris H or acetyl, and Ris H or Cto Calkyl, the method comprising: reacting a compound of formula I wherein the compound is an ester whereby Ris Cto Calkyl with a lipase derived from to stereoselectively hydrolyze the ester bond to produce an acid; and isolating the acid, wherein the reaction is conducted in a solvent comprising 80% to 98% v/v % organic phase and a residue of water phase (which can be buffered).

Enzymatic Ammonolysis Process For The Preparation Of Intermediates For Dpp Iv Inhibitors

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US Patent:
7223573, May 29, 2007
Filed:
May 2, 2005
Appl. No.:
11/119552
Inventors:
Ramesh N. Patel - Bridgewater NJ, US
Ronald L. Hanson - Morris Plains NJ, US
Iqbal Gill - Denville NJ, US
David B. Brzozowski - Pattersonville NY, US
Paul M. Skonezny - Baldwinsville NY, US
Michael M. Politino - Syracuse NY, US
Jason G. Chen - Manlius NY, US
Brenda J. White - Jamesville NY, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12P 17/10
C07D 207/22
US Classification:
435121, 548536
Abstract:
An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme lipase-B is used to catalyze the ammonolysis process.

Process For Preparing (2R,3S)-1,2-Epoxy-3-(Protected)Amino-4-Substituted Butane And Intermediates Thereof

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US Patent:
7582468, Sep 1, 2009
Filed:
Mar 1, 2006
Appl. No.:
11/365275
Inventors:
Nigel Ian Bowers - Yardley PA, US
Paul M. Skonezny - Baldwinsville NY, US
Gregory L. Stein - Mallory NY, US
Thomas Franceschini - Cicero NY, US
Shu-Jen Chiang - Manlius NY, US
Wendy L. Anderson - Mexico NY, US
Li You - Jamesville NY, US
Zizhuo Xing - Syracuse NY, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12P 41/00
US Classification:
435280, 435155
Abstract:
The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized having ATCC deposit no. PTA-6648.

Enzymatic Ammonolysis Process For The Preparation Of Intermediates For Dpp Iv Inhibitors

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US Patent:
7611880, Nov 3, 2009
Filed:
Apr 18, 2007
Appl. No.:
11/736786
Inventors:
Ramesh N. Patel - Bridgewater NJ, US
Ronald L. Hanson - Morris Plains NJ, US
Iqbal Gill - Denville NJ, US
David B. Brzozowski - Pattersonville NY, US
Paul M. Skonezny - Baldwinsville NY, US
Michael M. Politino - Syracuse NY, US
Jason G. Chen - West Lake Village CA, US
Brenda J. White - Jamesville NY, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12N 9/20
C12P 17/10
C07D 207/22
US Classification:
435198, 435121, 548531, 548536
Abstract:
An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme lipase-B is used to catalyze the ammonolysis process.

Process For Preparing Dipeptidyl Peptidase Iv Inhibitors And Intermediates Therefor

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US Patent:
7741082, Jun 22, 2010
Filed:
Apr 12, 2005
Appl. No.:
11/104015
Inventors:
Michael Politino - Syracuse NY, US
Matthew M. Cadin - Auburn NY, US
Paul M. Skonezny - Baldwinsville NY, US
Jason G. Chen - Manlius NY, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12P 13/00
C12P 1/00
C12N 9/00
C12N 9/06
US Classification:
435128, 435 41, 435183, 435191
Abstract:
A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure.

Process For Preparing Dipeptidyl Peptidase Iv Inhibitors And Intermediates Therefor

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US Patent:
8222009, Jul 17, 2012
Filed:
Jun 17, 2010
Appl. No.:
12/817370
Inventors:
Michael Politino - Syracuse NY, US
Matthew M. Cadin - Auburn NY, US
Paul M. Skonezny - Baldwinsville NY, US
Jason G. Chen - Manlius NY, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C12P 13/00
C12P 1/00
C12N 9/00
C12N 9/06
C07C 13/28
US Classification:
435128, 435 41, 435183, 435191, 585352
Abstract:
A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure.

Process For Preparing Dipeptidyl Peptidase Iv Inhibitors And Intermediates Therefor

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US Patent:
8361761, Jan 29, 2013
Filed:
Jun 14, 2012
Appl. No.:
13/523733
Inventors:
Michael Politino - Syracuse NY, US
Matthew M. Cadin - Auburn NY, US
Paul M. Skonezny - Baldwinsville NY, US
Jason G. Chen - Manlius NY, US
Assignee:
Bristol Myers-Squibb Company - Princeton NJ
International Classification:
C12P 13/00
C12P 1/00
C12N 9/06
C07C 13/28
US Classification:
435128, 435 41, 435183, 435191, 585352
Abstract:
A process for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided which employs a BOC-protected amine of the structure.
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Paul M Skonezny from Baldwinsville, NY, age ~73 Get Report