Inventors:
Susan M. Daluge - Chapel Hill NC
Paul M. Skonezny - Clay NY
Barbara Roth - Chapel Hill NC
Barbara S. Rauckman - Durham NC
Assignee:
Burroughs Wellcome Co. - Research Triangle Park NC
International Classification:
C07D23949
C07D40106
C07D40506
A61K 31505
Abstract:
Compounds of the formula (II) ##STR1## or a salt, N-oxide or acyl derivative thereof, wherein Y is a group ##STR2## which is linked to the pyrimidinylmethyl moiety at the 1 or 7-position and is optionally substituted at the 2, 3, 4 or 6-position or at the 7-position when the linkage to the pyrimidinylmethyl moiety is at the 1-position wherein X is an oxygen or sulphur atom, a group CH. sub. 2, a group S(O). sub. n where n=1 or 2, a group NR. sup. 1 wherein R. sup. 1 is hydrogen C. sub. 1-4 alkyl or a group COR. sup. 2 where R. sup. 2 is hydrogen, C. sub. 1-4 alkoxy or amino and the dotted line represents a single or double bond, have antimicrobial activity. Processes for making these compounds, pharmaceutical compositions containing them and the medical use of the compounds are also disclosed.