Inventors:
John David Charles Rosamund - Waltham MA, US
Norbert Friedemann Schnell - Waltham MA, US
Assignee:
AstraZeneca AB - Sodertalje
International Classification:
C12N 1/14
C12Q 1/68
C12P 21/06
C07H 21/04
A61K 39/00
US Classification:
43525422, 435 6, 4352523, 4352541, 4241841, 4241851, 4242741, 514 2, 514 15, 536 231, 536 237
Abstract:
This invention relates to polynucleotides, polypeptides encoded by these polynucleotides, to the production of such polynucleotides and polypeptides, and to the uses of such polynucleotides and polypeptides. More specifically, the invention relates to the phosphomevalonate kinase (PMK) gene (ERG8 gene) from (), to methods for its expression yielding phosphomevalonate kinase protein, to hybrid organisms for use in such expression methods, to methods for purification of the protein, to methods and tools for diagnosing infection and to assays for identifying inhibitors of the enzyme which inhibitors have potential as anti-fungal agents.