US Patent:
20060084141, Apr 20, 2006
Inventors:
Heinz Floss - Bellevue WA, US
Eckhard Leistner - Meckenheim, DE
International Classification:
C12P 17/18
C07H 21/04
C12P 21/06
C12N 9/10
C12N 1/21
C12N 15/74
US Classification:
435069100, 536023200, 435193000, 435320100, 435252350, 435119000, 540462000
Abstract:
The present invention relates to compositions and methods involving antitumor agents derived from bacteria. In particular, the present invention provides the ansamitocin biosynthetic gene cluster for the production of novel maytansinoid analogs with potent antitumor activity and reduced human toxicity.