Inventors:
Keith D. Combrink - Arlington TX, US
Suchismita Mohapatra - Arlington TX, US
Mark R. Hellberg - Arlington TX, US
Najam A. Sharif - Arlington TX, US
Ganesh Prasanna - Fort Worth TX, US
Iok-Hou Pang - Grand Prairie TX, US
Bryon Severns - Arlington TX, US
Hwang-Hsing Chen - Fort Worth TX, US
Abdelmoula Namil - Arlington TX, US
Assignee:
ASTELLAS PHARMA INC. - Chuo-ku Tokyo
ALCON RESEARCH, LTD. - Fort Worth TX
International Classification:
A61K 31/4439
C07D 401/14
A61K 31/444
C07D 498/04
A61K 31/496
A61K 31/4545
A61K 31/506
C07D 413/14
A61K 31/5377
C07D 471/04
C07D 401/12
A61K 31/4709
C07D 403/04
A61K 31/4184
A61P 27/02
A61P 27/06
A61P 9/12
C07D 401/06
US Classification:
5142345, 5462737, 514338, 546256, 514333, 546116, 514302, 544364, 51425309, 546194, 514318, 544331, 514275, 544131, 546121, 514300, 544362, 51425304, 546153, 514312, 544333, 514256, 546162, 514313, 5483061, 514395
Abstract:
The invention provides compositions and methods for treating and/or preventing ocular disorders associated with increased intraocular pressure. In particular, the compounds are bradykinin agonists.