Search

Frank A Skraly

from Watertown, MA
Age ~56
Get Report
Also known as:
Frank Anthony Skraly
Phone and address:
32 Spruce St, Watertown, MA 02472
Related to:
Monica A Skraly, 59Wanda Skraly
Connected to:
Judy L Skram, 67Harold C Skramstad, 95Larry E Skramstad, 82Dale L Skran, 67Debbie J Skrandzius, 64Christopher D Skrant, 51Janette L Skrasek, 79Robin M Skratsky, 70Scott A Skratulia, 42Snezana Skrbic, 49

Frank Skraly Phones & Addresses

  • 32 Spruce St, Watertown, MA 02472
  • 32 Spruce St #A, Watertown, MA 02472
  • McKeesport, PA
  • 39 Bay State Rd, Boston, MA 02215
  • 156 Raymond St, Cambridge, MA 02140
  • Somerville, MA
  • Madison, WI

Work

Company: Metabolix Jan 2017 Position: Senior director, metabolic engineering

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of Wisconsin - Madison 1990 to 1997 Specialities: Chemical Engineering

Skills

Molecular Biology • Cell Culture • Life Sciences • Hplc • Research • Pcr • Engineering • Microbiology • Biofuels • Chemical Engineering • Technology Transfer • R&D • Metabolic Engineering • Biotechnology • Process Optimization • Biochemistry • Process Simulation • Chemistry • Process Engineering

Industries

Biotechnology

Resumes

Resumes

Frank Skraly Photo 1

Senior Director, Metabolic Engineering

View page
Location:
70 Bates Rd, Watertown, MA 02472
Industry:
Biotechnology
Work:
Metabolix
Senior Director, Metabolic Engineering
Vl40 Jul 2016 - Jan 2017
Senior Director of R and D
Joule Unlimited Technologies, Inc. Jan 2008 - Apr 2016
Director and Senior Director, Metabolic Engineering
Metabolix Mar 1997 - Dec 2007
Team Leader, Microbial Metabolic Engineering
Education:
University of Wisconsin - Madison 1990 - 1997
Doctorates, Doctor of Philosophy, Chemical Engineering Penn State University 1986 - 1990
Bachelors, Bachelor of Science, Chemical Engineering
Skills:
Molecular Biology
Cell Culture
Life Sciences
Hplc
Research
Pcr
Engineering
Microbiology
Biofuels
Chemical Engineering
Technology Transfer
R&D
Metabolic Engineering
Biotechnology
Process Optimization
Biochemistry
Process Simulation
Chemistry
Process Engineering

Business Records

Name / Title
Company / Classification
Phones & Addresses
Frank Skraly
Director of Data Processing, Team Leader Microbial Metabolic Engineering, Research Manager
Metabolix
Biotechnology · Commercial Physical Research · Plastics Material & Resin Mfg
21 Erie St, Cambridge, MA 02139
(617) 583-1700, (617) 492-0505, (617) 583-1768

Publications

Us Patents

Medical Devices And Applications Of Polyhydroxyalkanoate Polymers

View page
US Patent:
6548569, Apr 15, 2003
Filed:
Mar 24, 2000
Appl. No.:
09/535146
Inventors:
Simon F. Williams - Sherborn MA
David P. Martin - Arlington MA
Frank A. Skraly - Somerville MA
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C08L 6704
US Classification:
523124, 521 17, 521 27, 521539, 525411, 525450
Abstract:
Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Polyhydroxyalkanoate Production From Polyols

View page
US Patent:
6576450, Jun 10, 2003
Filed:
Aug 30, 2001
Appl. No.:
09/944243
Inventors:
Frank A. Skraly - Boston MA
Oliver P. Peoples - Arlington MA
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C12P 762
US Classification:
435135
Abstract:
Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase -ketothiolase, acetoacetyl-CoA reductase, PHA synthase, glycerol-3-phosphate dehydrogenase and glycerol-3-phosphatase, which are useful for the production of PHAs. In some cases one or more of these genes are native to the host organism and the remainder are provided from transgenes. These organisms produce poly (3-hydroxyalkanoate) homopolymers or co-polymers incorporating 3-hydroxypropionate or 3-hydroxyvalerate monomers wherein the 3-hydroxypropionate and 3-hydroxyvalreate units are derived from the enzyme catalysed conversion of diols. Suitable diols that can be used include 1,2-propanediol, 1,3 propanediol and glycerol. Biochemical pathways for obtaining the glycerol from normal cellular metabolites are also described. The PHA polymers are readily recovered and industrially useful as polymers or as starting materials for a range of chemical intermediates including 1,3-propanediol, 3-hydroxypropionaldehyde, acrylics, malonic acid, esters and amines.

Transgenic Microbial Polyhydroxyalkanoate Producers

View page
US Patent:
6593116, Jul 15, 2003
Filed:
Aug 17, 1999
Appl. No.:
09/375975
Inventors:
Gjalt W. Huisman - San Carlos CA
Oliver P. Peoples - Arlington MA
Frank A. Skraly - Boston MA
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C12P 762
US Classification:
435135, 435143, 435146, 435183, 435190, 435191, 435193, 435232, 435375, 4352523, 4353201, 435829, 435831, 435877, 536 232
Abstract:
Transgenic microbial strains are provided which contain the genes required for PHA formation integrated on the chromosome. The strains are advantageous in PHA production processes, because (1) no plasmids need to be maintained, generally obviating the required use of antibiotics or other stabilizing pressures, and (2) no plasmid loss occurs, thereby stabilizing the number of gene copies per cell throughout the fermentation process, resulting in homogeneous PHA product formation throughout the production process. Genes are integrated using standard techniques, preferably transposon mutagenesis. In a preferred embodiment wherein mutiple genes are incorporated, these are incorporated as an operon. Sequences are used to stabilize mRNA, to induce expression as a function of culture conditions (such as phosphate concentration), temperature, and stress, and to aid in selection, through the incorporation of selection markers such as markers conferring antibiotic resistance.

Polyhydroxyalkanoate Compositions Having Controlled Degradation Rates

View page
US Patent:
6610764, Aug 26, 2003
Filed:
Dec 22, 1998
Appl. No.:
09/218575
Inventors:
David P. Martin - Arlington MA
Frank Skraly - Boston MA
Simon F. Williams - Sherborn MA
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C08L 6704
US Classification:
523124, 524 17, 524 27, 524559, 525411, 525450
Abstract:
Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physiological conditions.

Polyhydroxyalkanoate Compositions Having Controlled Degradation Rates

View page
US Patent:
6828357, Dec 7, 2004
Filed:
Mar 28, 2003
Appl. No.:
10/403242
Inventors:
David P. Martin - Arlington MA
Frank Skraly - Somerville MA
Simon F. Williams - Sherborn MA
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C08L 6704
US Classification:
523124, 6048901, 6048911, 606 72, 606 77
Abstract:
Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physioogical conditions.

Medical Devices And Applications Of Polyhydroxyalkanoate Polymers

View page
US Patent:
6838493, Jan 4, 2005
Filed:
Feb 26, 2002
Appl. No.:
10/082954
Inventors:
Simon F. Williams - Sherborn MA, US
David P. Martin - Arlington MA, US
Frank A. Skraly - Somerville MA, US
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C08L 6704
A61F 1300
US Classification:
523124, 523128, 602 4, 602 42, 604 9, 604 48, 606 72, 606151, 606228
Abstract:
Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Medical Devices And Applications Of Polyhydroxyalkanoate Polymers

View page
US Patent:
6867247, Mar 15, 2005
Filed:
May 1, 2002
Appl. No.:
10/136499
Inventors:
Simon F. Williams - Sherborn MA, US
David P. Martin - Arlington MA, US
Frank A. Skraly - Somerville MA, US
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C08L067/04
US Classification:
523124
Abstract:
Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

Polyhydroxyalkanoate Compositions Having Controlled Degradation Rates

View page
US Patent:
6867248, Mar 15, 2005
Filed:
Mar 28, 2003
Appl. No.:
10/403244
Inventors:
David P. Martin - Arlington MA, US
Frank Skraly - Somerville MA, US
Simon F. Williams - Sherborn MA, US
Assignee:
Metabolix, Inc. - Cambridge MA
International Classification:
C08L067/04
US Classification:
523124, 524558, 524559, 264166
Abstract:
Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physiological conditions.
Control profile
Frank A Skraly from Watertown, MA, age ~56 Get Report