US Patent:
20190086371, Mar 21, 2019
Inventors:
- Milford MA, US
Mathew H. DeLano - Needham MA, US
Scott A. McCall - Smithfield RI, US
Jonathan L. Belanger - Whitinsville MA, US
Theodore A. Dourdeville - Falmouth MA, US
Kerri M. Smith - Marlborough MA, US
Paul D. Rainville - Princeton MA, US
Dimple D. Shah - Medway MA, US
Stephen J. Shiner - Holden MA, US
Catalin Doneanu - Franklin MA, US
Michael Donegan - Charlton MA, US
Assignee:
Waters Technologies Corporation - Milford MA
International Classification:
G01N 30/56
G01N 30/60
G01N 30/72
C23C 14/24
C23C 14/12
C23C 14/04
Abstract:
A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I:R, R, R, R, R, and Rare each independently selected from (C-C)alkoxy, —NH(C-C)alkyl, —N((C-C)alkyl), OH, OR, and halo. Rrepresents a point of attachment to the interior surfaces of the fluidic system. At least one of R, R, R, R, R, and Ris OR. X is (C-C)alkyl, —O[(CH)O]—, —(C-C)[NH(CO)NH(C-C)]-, or —(C-C)[alkylphenyl(C-C)alkyl]-.
