Resumes
Resumes
Anindita Roy Phones & Addresses
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San Diego, CA
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Washington, UT
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Santa Clara, UT
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Salt Lake City, UT
Publications
Us Patents
Methods For Manufacturing An Electrochemical Sensor For Effective Diagnostic Oligonucleotide Detection
View pageUS Patent:
20220326173, Oct 13, 2022
Filed:
Apr 7, 2022
Appl. No.:
17/715816
Inventors:
- Salt Lake City UT, US
Eve F. Fabrizio - Salt Lake City UT, US
Anindita Roy - Salt Lake City UT, US
Tyler Archibald - Salt Lake City UT, US
Eve F. Fabrizio - Salt Lake City UT, US
Anindita Roy - Salt Lake City UT, US
Tyler Archibald - Salt Lake City UT, US
International Classification:
G01N 27/327
C25F 1/00
C25F 1/00
Abstract:
The present invention features methods for manufacturing an electrochemical sensor for detecting a diagnostic target oligonucleotide. The methods described herein provide for an electrochemical sensor with a higher level of coverage of the probes on its surface, thus allowing for more sensitive detection of a target oligonucleotide. The methods may feature first mixing disulfide terminated oligonucleotides having a free thiol moiety at the 3′ end with a gold substrate and subsequently introducing to the gold substrate a composition for reducing thiol moieties to cause the oligonucleotides to bind to the surface of the gold substrate. In some embodiments, the method comprises removing excess thiol and oligonucleotides, which may help with non-competitive binding. In some embodiments, the method comprises rinsing the gold substrate with water and drying with nitrogen.