US Patent:
20130095499, Apr 18, 2013
Inventors:
Brown University - Providence RI, US
Jack R. Wands - East Greenwich RI, US
Danielle Rand - Quincy MA, US
Zoltan Derdak - Riverside RI, US
Vivian Ortiz - Nashville TN, US
Assignee:
Brown University - Providence RI
International Classification:
G01N 33/574
Abstract:
Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.