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Zheng-Yi Chen

from Somerville, MA
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Connected to:
Abre G Chen, 65Adele Chen, 52Adeline K Chen, 39Ai M Chen, 60Ai C Chen, 78Aiping Chen, 63Alen Y Chen, 68Alma Chen, 29Amanda Chen, 44Amanda T Chen, 62

Zheng-Yi Chen Phones & Addresses

  • 22 Hudson St, Somerville, MA 02143 (617) 625-0746
  • 24 Hudson St, Somerville, MA 02143 (617) 625-0746

Work

Company: Mass. eye and ear Feb 2008 Position: Associate professor

Education

Degree: Doctorates, Doctor of Philosophy School / High School: University of Oxford 1987 to 1992

Skills

Clinical Research • Molecular Biology • Research • Medicine • Biochemistry • Biotechnology • Cell Biology • Cell Culture • Data Analysis • Healthcare • Healthcare Management • Hospitals • Life Sciences • Genetics • Healthcare Information Technology • Powerpoint • Public Health • Medical Education

Industries

Hospital & Health Care

Resumes

Resumes

Zheng-Yi Chen Photo 1

Associate Professor

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Location:
Somerville, MA
Industry:
Hospital & Health Care
Work:
Mass. Eye and Ear
Associate Professor
Education:
University of Oxford 1987 - 1992
Doctorates, Doctor of Philosophy
Skills:
Clinical Research
Molecular Biology
Research
Medicine
Biochemistry
Biotechnology
Cell Biology
Cell Culture
Data Analysis
Healthcare
Healthcare Management
Hospitals
Life Sciences
Genetics
Healthcare Information Technology
Powerpoint
Public Health
Medical Education

Publications

Us Patents

Islet1 (Isl1) And Hearing Loss

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US Patent:
20120222141, Aug 30, 2012
Filed:
Jun 22, 2010
Appl. No.:
13/380143
Inventors:
Mingqian Huang - Winchester MA, US
Zheng-Yi Chen - Somerville MA, US
Assignee:
MASSACHUSETTS EYE & EAR INFIRMARY - Boston MA
International Classification:
A61K 38/02
A01K 67/027
C12N 5/10
A61K 31/7088
C12Q 1/68
G01N 33/567
US Classification:
800 9, 435 611, 435 721, 514 11, 435354, 514 44 R
Abstract:
Described are methods and compositions for increasing islet-1 (Isl1) activity (e.g., biological activity) and or expression (e.g., transcription and/or translation) in a biological cell and or in a subject.

Methods And Products Related To The Production Of Inner Ear Hair Cells

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US Patent:
20060024278, Feb 2, 2006
Filed:
Jan 24, 2005
Appl. No.:
11/041907
Inventors:
Zheng-Yi Chen - Somerville MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 48/00
US Classification:
424093210, 514044000
Abstract:
The invention relates to the generation of inner ear sensory epithelial cells through the manipulation of the expression level or function of the genes and/or proteins involved in the retinoblastoma (Rb) pathway, particularly retinoblastoma family members, such as Rb1. Methods for generating inner ear sensory epithelial cells and for restoring hearing or balance in a subject, therefore, are provided. The invention further relates to cell lines of inner ear sensory epithelial cells, such as progenitor, supporting or hair cells, where the expression level or function of the retinoblastoma genes and/or retinoblastoma proteins has been manipulated. In addition to these methods, compositions of agents for use in or the cells produced by such methods provided are also included. Finally, the invention also relates to methods and compositions for the generation of inner ear sensory epithelial cells through the manipulation of Isl-1 alone or in combination with the manipulation of retinoblastoma gene and/or retinoblastoma protein.

Methods And Compositions For Regenerating Hair Cells And/Or Supporting Cells

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US Patent:
20200338160, Oct 29, 2020
Filed:
Apr 7, 2020
Appl. No.:
16/842309
Inventors:
- Boston MA, US
Zheng-Yi Chen - Somerville MA, US
Assignee:
Massachusetts Eye and Ear Infirmary - Boston MA
International Classification:
A61K 38/17
C12N 5/0793
A61K 38/16
A61K 31/65
A61K 48/00
Abstract:
Provided are methods and compositions for inducing cells of the inner ear (for example, cochlear and utricular hair cells) to reenter to cell cycle and to proliferate. More particularly, the invention relates to the use of agents that increase c-myc activity and/or Notch activity for inducing cell cycle reentry and proliferation of cochlear or utricular hair cells and/or cochlear or utricular supporting cells. The methods and compositions can be used to promote the proliferation of hair cells and/or supporting cells to treat a subject at risk of, or affected with, hearing loss or a subject at risk of, or affected with vestibular dysfunction.

Efficient Delivery Of Therapeutic Molecules To Cells Of The Inner Ear

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US Patent:
20170327557, Nov 16, 2017
Filed:
Oct 29, 2015
Appl. No.:
15/523317
Inventors:
- Boston MA, US
Zheng-Yi Chen - Somerville MA, US
International Classification:
C07K 14/705
C07K 14/435
C07K 14/47
A61K 9/00
C12N 5/071
C12N 5/0793
C07K 14/46
A61K 38/00
Abstract:
Compositions and provided to induce cells of the inner ear to renter the cell cycle and to proliferate. In particular, hair cells are induced to proliferate by administration of a composition which activates the Myc and Notch. Supporting cells are induced to transdifferentiate to hair cells by inhibition of Myc and Notch activity or the activation of Atoh1. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

Method For Efficient Delivery Of Therapeutic Molecules In Vitro And In Vivo

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US Patent:
20170247672, Aug 31, 2017
Filed:
Oct 29, 2015
Appl. No.:
15/523321
Inventors:
- Boston MA, US
Zheng-Yi Chen - Somerville MA, US
International Classification:
C12N 9/22
C12N 15/90
C12N 15/113
Abstract:
Compositions are described for direct protein delivery into multiple cell types in the mammalian inner ear. The compositions are used to deliver protein(s) (such as gene editing factors) editing of genetic mutations associated with deafness or associated disorders thereof. The delivery of genome editing proteins for gene editing and correction of genetic mutations protect or restore hearing from genetic deafness. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.

Islet1 (Isl1) And Hearing Loss

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US Patent:
20160061818, Mar 3, 2016
Filed:
Sep 14, 2015
Appl. No.:
14/853527
Inventors:
- Boston MA, US
Zheng-Yi Chen - Somerville MA, US
International Classification:
G01N 33/50
C12Q 1/68
A61K 45/06
A61K 38/17
A61K 9/00
Abstract:
Described are methods and compositions for increasing islet-1 (Isl1) activity (e.g., biological activity) and or expression (e.g., transcription and/or translation) in a biological cell and or in a subject.

Methods And Compositions For Regenerating Hair Cells And/Or Supporting Cells

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US Patent:
20150209406, Jul 30, 2015
Filed:
Sep 6, 2013
Appl. No.:
14/426520
Inventors:
- Boston MA, US
Zheng-Yi Chen - Somerville MA, US
International Classification:
A61K 38/17
C12N 5/0793
Abstract:
Provided are methods and compositions for inducing cells of the inner ear (for example, cochlear and utricular hair cells) to reenter to cell cycle and to proliferate. More particularly, the invention relates to the use of agents that increase c-myc activity and/or Notch activity for inducing cell cycle reentry and proliferation of cochlear or utricular hair cells and/or cochlear or utricular supporting cells. The methods and compositions can be used to promote the proliferation of hair cells and/or supporting cells to treat a subject at risk of or affected with, hearing loss or a subject at risk of or affected with vestibular dysfunction.
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Zheng-Yi Chen from Somerville, MA Get Report