Inventors:
Dai Cheng - San Diego CA, US
Dong Han - San Diego CA, US
Guobao Zhang - San Diego CA, US
Yongqin Wan - Irvine CA, US
Yun Feng Xie - San Diego CA, US
Jiqing Jiang - San Diego CA, US
Wenqi Gao - San Diego CA, US
Shifeng Pan - San Diego CA, US
International Classification:
C07D 401/12
C07D 473/00
C07D 401/14
C07D 405/14
C07D 409/14
C07D 471/04
US Classification:
51425204, 546141, 514309, 546143, 514310, 546140, 514308, 544279, 51426411, 544238, 546122, 514300, 544333, 514256, 544277, 51426322, 544405, 51425505
Abstract:
The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).