US Patent:
20110263610, Oct 27, 2011
Inventors:
Yongqin Wan - Irvine CA, US
Shifeng Pan - San Diego CA, US
Guobao Zhang - San Diego CA, US
Xia Wang - San Diego CA, US
Yun Feng Xie - San Diego CA, US
Jiqing Jiang - San Diego CA, US
Dean Phillips - San Marcos CA, US
Yang Yang - San Diego CA, US
International Classification:
C07D 487/04
C07D 405/14
A61P 19/02
A61P 17/06
A61P 37/00
A61K 31/496
C07D 401/14
US Classification:
51425305, 51425304, 51425309, 544362, 544364, 544363
Abstract:
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).