Yu Y Chen

7091396, Aug 15, 2006

Oct 17, 2001

09/982120

Sanford M. Simon - New York NY, US
Yu Chen - New York NY, US

The Rockefeller University - New York NY

A01K 67/027
A01K 67/033
C12N 15/63
C12N 5/06
C12N 5/10

800 18, 800 13, 435326, 435325, 435455, 4353201

Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.

20020103821, Aug 1, 2002

Jan 26, 2001

09/772319

Lira Nikolovska - Eindhoven, NL
Nevenka Dimitrova - Yorktown Heights NY, US
Yu Chen - New York NY, US

PHILIPS ELECTRONICS NORTH AMERICA CORPORATION

G06F017/00

707/500100

A user interface system is disclosed for use in a video display system that is capable of simultaneously displaying a main multimedia document and a plurality of additional multimedia documents on a display screen. The video display system displays the main multimedia document on a central portion of the display screen. The user interface system receives a user instruction that selects a format for displaying the plurality of additional multimedia documents. The plurality of additional multimedia documents may be displayed in a collage format in which the individual additional multimedia documents are located around the periphery of the main multimedia document. The plurality of additional multimedia documents may also be displayed in one or more horizontal lines or in one or more vertical lines. The user interface system is capable of receiving user instructions to control the display of the plurality of additional multimedia documents.

20030049597, Mar 13, 2003

Mar 1, 2001

09/797496

Sanford Simon - New York NY, US
Yu Chen - New York NY, US

C12Q001/00
C12Q001/37
C12N015/87

435/004000, 435/023000, 435/455000

Method for similtaneously quantifying in situ the relationship between an enzyme and its substrate, especially by the use of fluorescence.

20060288430, Dec 21, 2006

Jun 23, 2006

11/474133

Sanford Simon - New York NY, US
Yu Chen - New York NY, US

A01K 67/027

800006000, 800014000

Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.

20090193530, Jul 30, 2009

Dec 12, 2008

12/316433

Sanford M. Simon - New York NY, US
Yu Chen - New York NY, US

A01K 67/027
C12N 15/85
C12N 5/06
C07K 16/18

800 6, 800 14, 435328, 5303917

Genetically-modified mammals and immune cells are provided which are capable of producing or secreting detectably-labeled immunoglobulin molecules as a result of genetic modifications of at least one immunoglobulin gene in the genome thereof, such that a fusion polynucleotide encoding a detectable protein or peptide and an immunoglobulin component molecule is present.

62040677, Mar 20, 2001

Jun 17, 1999

9/335457

Sanford M. Simon - New York NY
Melvin S. Schindler - Okemos MI
Yu Chen - New York NY

Board of Trustees Operating Michigan State University - East Lansing MI

G01N 3122
G01N 2180
G01N 3348
C07C21104

436163

The present invention discloses the mechanism of tamoxifen mediated inhibition of acidification. This mechanism information is then used to design methods of identifying compounds that will have the pharmaceutical effect of tamoxifen without the corresponding side-effects.

20190292529, Sep 26, 2019

Jan 25, 2019

16/258477

- New York NY, US
Thomas WIESNER - New York NY, US
Yu CHEN - New York NY, US

Memorial Sloan Kettering Cancer Center - New York NY

C12N 9/12
A61K 31/5377
A61K 31/545
G01N 33/574
A61K 31/4545
C12Q 1/6886
A61K 31/506

The present invention relates to a Truncated isoform of Anaplastic Lymphoma Kinase (“TALK”). Expression of this isoform is associated with malignancy and with responsiveness to ALK inhibitors. Detection of the isoform may be used in diagnostic and therapeutic methods. Because it arises as a result of variant transcription rather than genetic rearrangement, its presence would be undetected by genomic testing.

20190250989, Aug 15, 2019

Apr 23, 2019

16/392487

- Redmond WA, US
Jin LI - Bellevue WA, US
Aaron William OGUS - Woodinville WA, US
Douglas W. PHILLIPS - Woodinville WA, US
Yu Lin CHEN - New York NY, US
Shuai MU - New York NY, US
Jinyang LI - New York NY, US

G06F 11/10
H03M 13/15
G06F 12/02
H03M 13/37
G06F 11/16

In various embodiments, methods and systems for implementing distributed data object management are provided. The distributed data object management system includes a distributed storage system having a local metadata-consensus information store in and one or more remote metadata-consensus information stores. A metadata-consensus information store is configured to store metadata-consensus information. The metadata-consensus information corresponds to erasure coded fragments of a data object and instruct on how to manage the erasure coded fragments. The distributed storage system further includes a local data store and one or more remote data stores for the erasure coded fragments. The distributed data object management system includes a distributed data object manager for operations including, interface operations, configuration operations, write operations, read operations, delete operations, garbage collection operations and failure recovery operations. The distributed data object management system is operates based on metadata paths and data paths, operating in parallel, for write operations and read operations.