US Patent:
20060134195, Jun 22, 2006
Inventors:
Yourong Fu - West Lafayette IN, US
Seong Jeong - West Lafayette IN, US
Jeanny Kim - West Lafayette IN, US
Jacqueline Callihan - West Lafayette IN, US
Kinam Park - West Lafayette IN, US
Chaul Pai - Daejeon, KR
Sang Yeob Park - Daejeon, KR
Gun Seomoon - Daejeon, KR
International Classification:
A61K 9/20
Abstract:
Fast-dissolving pharmaceutical tablets comprising mannose are described. The mannose component imparts both structure-forming and fast-dissolution properties to the tablets. Granulation of tablet components and humidification forms strong liquid bridges at the surface interfaces of mannose particles, which leads to strengthened tablets. The mannose particles, however, remain porous following compression so that contact with moisture, e.g., saliva in the mouth, leads rapidly to tablet disintegration and dissolution.