US Patent:
20040209283, Oct 21, 2004
Inventors:
Yoshihiko Yagi - Kalamazoo MI, US
Michael Sheets - Somerset WI, US
Peter Wells - La Jolla CA, US
John Shelly - New Hudson MI, US
Roger Poorman - Portage MI, US
Dennis Epps - Jacksonville FL, US
Aric Morgan - Portage MI, US
Assignee:
Pfizer Inc. - New York NY
International Classification:
C12Q001/70
C12Q001/68
Abstract:
The invention provides a method for detecting RNA polymerase activity in a continuous-read manner. Specifically, the invention provides a method for detecting the de novo polymerase activity of the Hepatitis C virus (HCV) polymerase, NS5B, in a continuous-read manner. The invention also provides a method of screening for modulators of RNA polymerase activity. More specifically, the invention provides a method of screening for modulators of HCV NS5B activity.