US Patent:
20080021044, Jan 24, 2008
Inventors:
Mitul Patel - Union NJ, US
Christopher Nilsen - Branchburg NJ, US
Mayra Reyes - Somerset NJ, US
Michael Humora - Cranbury NJ, US
Yun Qian - Doylestown PA, US
Fuqiang Liu - Lansdale PA, US
Xini Zhang - Bridgewater NJ, US
Kirk Sorgi - Doylestown PA, US
International Classification:
A61K 31/4965
A61P 7/02
C07D 241/08
Abstract:
The present invention is directed to N-[2-[[(diaminomethylene)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-s-oxo-1(2H)-pyrazineacetamide, pharmaceutical compositions containing said compound and methods of treatment comprising inhibiting a serine protease using said compound. The present invention is further directed to a process for the preparation of the N-[2-[[(diaminomethylene)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxo-1(2H)-pyrazineacetamide as a free base. The present invention is further directed to a process for the preparation of pharmaceutically acceptable salts of N-[2-[[(aminoiminomethyl)amino]oxy]ethyl]-3-[(2,2-difluoro-2-phenylethyl)amino]-6-methyl-2-oxo-1(2H)-pyrazineacetamide.