Xin Guo

20110118262, May 19, 2011

Jun 24, 2009

13/002658

Joerg Martin Bentzien - White Plains NY, US
Stephen James Boyer - Bethany CT, US
Jennifer Burke - Cheshire CT, US
Anne Bettina Eldrup - Newtown CT, US
Xin Guo - Danbury CT, US
John David Huber - New York NY, US
Thomas Martin Kirrane - Middlebury CT, US
Fariba Soleymanzadeh - Danbury CT, US
Alan David Swinamer - Southbury CT, US

BOEHRINGER INGELHEIM INTERNATIONAL GMBH - Ingelheim am Rhein

A61K 31/5377
C07D 401/14
A61K 31/4545
A61K 31/451
C07D 401/10
A61K 31/4525
C07D 401/06
A61K 31/506
A61K 31/4709
C07D 413/06
A61K 31/437
C07D 207/08
A61K 31/40
A61P 9/00

5142355, 546194, 514318, 546226, 514330, 546214, 514326, 546196, 514320, 544335, 514256, 544332, 514275, 546168, 514314, 544130, 546121, 514300, 546189, 514316, 548539, 514423

Disclosed are compounds of formula (I) and compositions of the present invention which are inhibitors of the sodium proton exchanger isoform-1 (NHE-I). Also disclosed are methods of using and making the same.

20210016071, Jan 21, 2021

Oct 1, 2020

17/061203

- Atlanta GA, US
Mark R. PRAUSNITZ - Atlanta GA, US
Sebastien HENRY - Smyrna GA, US
Xin Dong GUO - Atlanta GA, US

A61M 37/00

A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.

20180312475, Nov 1, 2018

Jan 28, 2016

15/545331

- Ingelheim am Rhein, DE
Jörg M. BENTZIEN - White Plains NY, US
Jennifer BURKE - Newtown CT, US
Derek COGAN - Ridgefield CT, US
Xin GUO - Danbury CT, US
Keith R. HORNBERGER - Southbury CT, US
John LORD - Poughkeepsie NY, US
Kenneth M. MEYERS - Seymour CT, US
Zhaoming XIONG - Ridgefield CT, US
Maolin YU - Brookfield CT, US
Zhonghua ZHANG - Ridgefield CT, US

C07D 261/20
C07D 413/10
C07D 413/04
C07D 413/06
C07D 413/12
C07D 498/04
A61P 13/12

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, wherein X, R, Rand Rare as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

20170050010, Feb 23, 2017

Apr 24, 2015

15/306152

- Atlanta GA, US
Mark PRAUSNITZ - Atlanta GA, US
Sebastien HENRY - Smyrna GA, US
Xin Dong GUO - Atlanta GA, US

A61M 37/00

A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.