Search

Xiaowei Zhuang

from Lexington, MA
Age ~52
Get Report
Also known as:
Xia O Zhuang, Hauang Z Xiaowei
Phone and address:
5 Luongo Farm Ln, Lexington, MA 02421
(781) 652-0103
Related to:
Lixian Zhuang
Connected to:
Alex Q Zhuang, 50Bill Zhuang, 59Bin Zhuang, 56Bixia Zhuang, 51Esther Z Zhuang, 42Jifang Zhuang, 48Ke Zhuang, 72Lan Zhuang, 55Ping J Zhuang, 50Qun Zhuang, 57

Xiaowei Zhuang Phones & Addresses

  • 5 Luongo Farm Ln, Lexington, MA 02421 (781) 652-0103
  • 165 Pleasant St, Cambridge, MA 02139
  • Mountain View, CA
  • Manalapan, NJ
  • Berkeley, CA
  • North Quincy, MA
  • Stoughton, MA

Publications

Wikipedia References

Xiaowei Zhuang Photo 2

Xiaowei Zhuang

About:
Born:

1972

Work:
Company:

Harvard University faculty

Position:

Investigator • Biophysicist

Education:
Studied at:

University of California, Berkeley • University of Science and Technology of China

Academic degree:

Member of the United States National Academy of Sciences • Professor

Skills & Activities:
Ascribed status:

American of Chinese descent

Achieved status:

MacArthur Fellow

Skill:

Sterilization

Wikipedia

Xiaowei Zhuang

View page

Xiaowei Zhuang is an American biophysicist, and Professor of Chemistry and Chemical Biology, and Physics, at Harvard University, and the Zhuang Research Lab. She is an Investigator ...

Us Patents

Sub-Diffraction Limit Image Resolution And Other Imaging Techniques

View page
US Patent:
7838302, Nov 23, 2010
Filed:
Feb 1, 2008
Appl. No.:
12/012524
Inventors:
Xiaowei Zhuang - Cambridge MA, US
Wilfred M. Bates - Somerville MA, US
Michael J. Rust - Medford MA, US
Bo Huang - Somerville MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
G01N 21/76
US Classification:
436172, 436164, 436171
Abstract:
The present invention generally relates to sub-diffraction limit image resolution. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. In one set of embodiments, the entities may be selectively activatable, i. e. , one entity can be activated to produce light, without activating other entities. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc.

Sub-Diffraction Limit Image Resolution In Three Dimensions

View page
US Patent:
8564792, Oct 22, 2013
Filed:
Dec 19, 2008
Appl. No.:
12/746784
Inventors:
Xiaowei Zhuang - Cambridge MA, US
Bo Huang - San Francisco CA, US
Wilfred M. Bates - Goettingen, DE
Wenqin Wang - Somerville MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
G01B 11/14
US Classification:
356624, 356614
Abstract:
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques, including imaging in three dimensions. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. In some cases, the position of the entities can be determined in all three spatial dimensions (i. e. , in the x, y, and z directions), and in certain cases, the positions in all three dimensions can be determined to an accuracy of less than about 1000 nm. In some cases, the z positions may be determined using one of a variety of techniques that uses intensity information or focal information (e. g. , a lack of focus) to determine the z position. Non-limiting examples of such techniques include astigmatism imaging, off-focus imaging, or multi-focal-plane imaging.

Sub-Diffraction Image Resolution And Other Imaging Techniques

View page
US Patent:
20080032414, Feb 7, 2008
Filed:
Nov 29, 2006
Appl. No.:
11/605842
Inventors:
Xiaowei Zhuang - Cambridge MA, US
Wilfred Mark Bates - Somerville MA, US
Michael J. Rust - Medford MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
G01N 21/76
US Classification:
436172
Abstract:
The present invention generally relates to sub-diffraction image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA or a protein. The entities may also be determined with respect to time, for example, to determine a time-varying reaction. Other aspects of the invention relate to systems for sub-diffraction image resolution, computer programs and techniques for sub-diffraction image resolution, methods for promoting sub-diffraction image resolution, methods for producing photoswitchable entities, and the like.

Sub-Diffraction Limit Image Resolution And Other Imaging Techniques

View page
US Patent:
20100297777, Nov 25, 2010
Filed:
Aug 4, 2010
Appl. No.:
12/850586
Inventors:
Xiaowei Zhuang - Cambridge MA, US
Wilfred M. Bates - Somerville MA, US
Michael J. Rust - Medford MA, US
Bo Huang - San Francisco CA, US
Graham Thomas Dempsey - Somerville MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
G01N 21/64
C07K 2/00
C07K 16/00
US Classification:
436172, 530402, 5303913
Abstract:
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined The entities may be immobilized relative to each other and/or to a common entity. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc. The entities may also be determined with respect to time, for example, to determine a time-varying reaction. Other aspects of the invention relate to systems for sub-diffraction limit image resolution, computer programs and techniques for sub-diffraction limit image resolution, methods for promoting sub-diffraction limit image resolution, methods for producing photoswitchable entities, and the like.

Sub-Diffraction Limit Image Resolution And Other Imaging Techniques

View page
US Patent:
20100316269, Dec 16, 2010
Filed:
Jun 7, 2010
Appl. No.:
12/795423
Inventors:
Xiaowei Zhuang - Cambridge MA, US
Wilfred M. Bates - Somerville MA, US
Michael J. Rust - Medford MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
G06K 9/62
US Classification:
382128
Abstract:
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc. The entities may also be determined with respect to time, for example, to determine a time-varying reaction. Other aspects of the invention relate to systems for sub-diffraction limit image resolution, computer programs and techniques for sub-diffraction limit image resolution, methods for promoting sub-diffraction limit image resolution, methods for producing photoswitchable entities, and the like.

Granular Nanoparticles Having Bright Fluorescence And Giant Raman Enhancements

View page
US Patent:
20110111518, May 12, 2011
Filed:
Nov 14, 2008
Appl. No.:
12/743184
Inventors:
Jie Zheng - Somerville MA, US
Xiaowei Zhuang - Lexington MA, US
International Classification:
G01N 21/76
US Classification:
436172
Abstract:
The present invention provides nanoparticles having bright fluorescence, where the total number of photons emitted from a single nanoparticle upon excitation with an excitation wavelength of the nanoparticle is at least 107, and giant Raman enhancements, where Raman signal for a molecule near a single nanoparticle increases at least 107 times. The nanoparticles of the invention comprise a plurality of crystallites that are each about 0.6 nm to about 10 nm in size. The present invention also provides methods for making the nanoparticles, which include mixing a matrix material with a reactant capable of being thermally reduced to form the nanoparticle; forming a mixed solid phase; and thermally reducing the mixed solid phase to form the nanoparticle.

Sub-Diffraction Image Resolution And Other Imaging Techniques

View page
US Patent:
20120009589, Jan 12, 2012
Filed:
Jul 11, 2011
Appl. No.:
13/179936
Inventors:
Xiaowei Zhuang - Cambridge MA, US
Wilfred M. Bates - Goettingen, DE
Michael J. Rust - Medford MA, US
Bo Huang - , US
Graham Thomas Dempsey - , US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
G01N 21/64
C12Q 1/68
US Classification:
435 619, 435 71
Abstract:
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc. The entities may also be determined with respect to time, for example, to determine a time-varying reaction. Other aspects of the invention relate to systems for sub-diffraction limit image resolution, computer programs and techniques for sub-diffraction limit image resolution, methods for promoting sub-diffraction limit image resolution, methods for producing photoswitchable entities, and the like.

Sub-Diffraction Image Resolution And Other Imaging Techniques

View page
US Patent:
20130001436, Jan 3, 2013
Filed:
Jul 17, 2012
Appl. No.:
13/551357
Inventors:
Xiaowei Zhuang - Lexington MA, US
Wilfred M. Bates - Goettingen, DE
Michael J. Rust - Medford MA, US
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
G01B 11/14
US Classification:
2504591, 250200
Abstract:
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two or more entities separated by a distance less than the diffraction limit of the incident light. For example, the entities may be separated by a distance of less than about 1000 nm, or less than about 300 nm for visible light. In one set of embodiments, the entities may be selectively activatable, i.e., one entity can be activated to produce light, without activating other entities. A first entity may be activated and determined (e.g., by determining light emitted by the entity), then a second entity may be activated and determined. The entities may be immobilized relative to each other and/or to a common entity. The emitted light may be used to determine the positions of the first and second entities, for example, using Gaussian fitting or other mathematical techniques, and in some cases, with sub-diffraction limit resolution. The methods may thus be used, for example, to determine the locations of two or more entities immobilized relative to a common entity, for example, a surface, or a biological entity such as DNA, a protein, a cell, a tissue, etc. The entities may also be determined with respect to time, for example, to determine a time-varying reaction. Other aspects of the invention relate to systems for sub-diffraction limit image resolution, computer programs and techniques for sub-diffraction limit image resolution, methods for promoting sub-diffraction limit image resolution, methods for producing photoswitchable entities, and the like.
Control profile
Xiaowei Zhuang from Lexington, MA, age ~52 Get Report