Inventors:
Xiaofeng Zhang - Boston MA, US
- Boston MA, US
Chengkui Pei - Brighton MA, US
Assignee:
DANA-FARBER CANCER INSTITUTE, INC. - Boston MA
International Classification:
C07D 405/14
C07D 401/14
C07D 401/12
C07D 295/192
C07D 233/70
C07D 333/38
C07D 213/81
C07C 237/34
C07D 413/14
C07D 493/04
Abstract:
Provided herein are compounds that inhibit histone lysine demethylase (KDM) and pharmaceutically acceptable salts, hydrates, solvates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, and prodrugs thereof, pharmaceutical compositions thereof, and methods of treating or preventing diseases (e.g., proliferative diseases, e.g., cancer). In certain embodiments, the compounds described herein are represented by formulas (I) and (II).
