Xiao J Chen

6720329, Apr 13, 2004

Mar 12, 2002

10/096804

Gregory R. Ott - Media PA
Xiao Tao Chen - Newark DE
Jingwu Duan - Newark DE
Matthew E. Voss - Lincoln University PA

Bristol-Myers Squibb Pharma - Princeton NJ

A61K 31443

514278, 514342, 514339, 514336, 546 15, 546152, 5462681, 5462764, 5462797, 5462817

The present application describes novel spiro-cyclic -amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF- converting enzyme (TACE), and/or aggrecanase inhibitors.

6962938, Nov 8, 2005

Dec 18, 2003

10/741326

Gregory R. Ott - Media PA, US
Xiao Tao Chen - Furlong PA, US
Jingwu Duan - Yardley PA, US
Matthew E. Voss - Lincoln University PA, US

Bristol-Myers Squibb Pharma Company - Princeton NJ

A61K031/403
A61K031/38
C07D327/04
C07D207/04
C07D207/18

514409, 514438, 514462, 549 30, 549200, 549300, 549322, 549337, 549341, 548407

The present application describes novel spiro-cyclic β-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), and/or aggrecanase inhibitors.

7511062, Mar 31, 2009

May 16, 2005

11/130359

Rongze Kuang - Green Brook NJ, US
David Blythin - North Caldwell NJ, US
Neng-Yang Shih - Warren NJ, US
Xiao Chen - Edison NJ, US
Jianhua Cao - Edison NJ, US
Danlin Gu - Kirkland WA, US
Ying Huang - Berkeley Heights NJ, US
John H. Schwerdt - Lake Hiawatha NJ, US
Pauline C. Ting - New Providence NJ, US
Li Xiao - Cranbury NJ, US

Schering Corporation - Kenilworth NJ

C07D 215/38
A61K 31/44

514312, 514314, 546153, 546159

The invention claims compounds of the formula.

7956189, Jun 7, 2011

Aug 10, 2007

11/891351

Xiaoming Chen - Westfield NJ, US
Xiao Chen - Edison NJ, US
Jianguo Yin - Plainsboro NJ, US
Xiaoyong Fu - Edison NJ, US
David J. Blythin - North Caldwell NJ, US
Rongze Kuang - Green Brook NJ, US
Scott Trzaska - Raritan NJ, US
Chee-Wah Tang - Singapore, SG
Vincenzo Liotta - Glen Ridge NJ, US
Zaher Shabani - Budd Lake NJ, US

Schering Corporation - Kenilworth NJ

C07D 215/38

546167

Disclosed are maleate, tosylate, fumarate, and oxalate salts of the compound 5-(1(S)-Amino-2-Hydroxyethyl)-N-[(2,4-Difluorophenyl)-Methyl]-2-[8-Methoxy-2-(Trifluoromethyl)-5-Quinoline]-4-Oxazolecarboxamide, represented by Formula I, and methods of preparing the same.

20130196902, Aug 1, 2013

Jan 31, 2013

13/755637

Dennis Yamashita - Wayne PA, US
Xiao Tao Chen - Furlong PA, US

Trevena, Inc. - King of Prussia PA

C07K 7/06

514 37, 530328, 514 217, 514 164

This application describes compounds acting as, for example, β-arrestin effectors and uses thereof, in, for example, the treatment of chronic and acute cardiovascular diseases.

20190055188, Feb 21, 2019

Feb 23, 2017

16/078572

- New Brunswick NJ, US
Ajit Parhi - New Brunswick NJ, US
Gifty A. Blankson - New Brunswick NJ, US
Liping Wang - Monmouth Junction NJ, US
Xiao Chen - Monmouth Junction NJ, US
Yongzheng Zhang - Monmouth Junction NJ, US
Malvika Kaul - New Brunswick NJ, US
Daniel S. Pilch - New Brunswick NJ, US

C07C 211/63
C07C 217/42
A61K 31/14
A61K 45/06
A61P 31/04

Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.