Xiao Chen

6436928, Aug 20, 2002

Dec 14, 2000

09/737036

Neng-Yang Shih - North Caldwell NJ
Gregory A. Reichard - Morris Plains NJ
Sunil Paliwal - Scotch Plains NJ
David J. Blythin - North Caldwell NJ
John J. Piwinski - Clinton Township NJ
Dong Xiao - Scotch Plains NJ
Xiao Chen - Edison NJ

Schering Corporation - Kenilworth NJ

A61K 314166

5142278, 514396, 514399, 514400, 5483165, 5483235

A compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar and Ar are optionally substituted heteroaryl or optionally substituted phenyl; X is âOâ, âSO â, âNR â, âNCOR â or âNR SO R ; âis X is âOâ, âSâ or optionally substituted nitrogen; Y is O, S or NR ; Y is H, alkyl, âNR R , âSCH , R -aryl(CH ) â, R -heteroaryl-(CH ) â, â(CH ) -heterocycloalkyl, -alkyl-NHâC(O)O-alkyl or âNHC(O)R ; R , R , R and R are H, alkyl, OH-alkyl, cycloalkyl, âCHF , âCH F or âCF ; or R and R form an alkylene ring; or R and R together are O; R is H, alkyl, âOR or âSR ; and the remaining variables are as defined in the specification, is disclosed, as well as a pharmaceutical compositions comprising said compound, methods of using said compound as a neurokinin antagonist, and the combination of said compounds with a selective serotonin reuptake inhibitor.

6635630, Oct 21, 2003

Jun 6, 2002

10/163663

Neng-Yang Shih - North Caldwell NJ
Gregory A. Reichard - Morris Plains NJ
Sunil Paliwal - Scotch Plains NJ
David J. Blythin - North Caldwell NJ
John J. Piwinski - Clinton Township NJ
Dong Xiao - Scotch Plains NJ
Xiao Chen - Edison NJ

Schering Corporation - Kenilworth NJ

A61K 31330

514183, 514396, 514397, 514398, 514400, 5483235, 5483215, 5483251, 5483255, 5483265, 548134

Compound represented by the structural formula or a pharmaceutically acceptable salt thereof, wherein Ar and Ar are optionally substituted heteroaryl or optionally substituted phenyl; X is âOâ, âSâ, âSOâ, âSO â, âNR â, âNCOR â or âNR SO R ; âis selected from the group consisting of X is âOâ, âSâ or âNR â; Y is O, S or NR ; Y is H, C -C alkyl, âNR R , âSCH , R -aryl(CH ) â, R -heteroaryl-(CH ) â, â(CH ) âheterocycloalkyl, â(C -C )alkyl-NHâC(O)O(C -C )alkyl or âNHC(O)R ; R is H or â(CH ) âG, wherein n is 0-5, G is H, âCF , âCHF , âCH F, âOH, âOâ(C -C alkyl), âSO R , âOâ(C -C cycloalkyl), âNR R , âSO NR R , âNR SO R , âNR COR , âNR (CONR R ), âCONR R , âCOOR , C -C cycloalkyl, R -aryl, R -heteroaryl, and provided when n =0, G is not H; R , R , R and R are H, alkyl, cycloalkyl, âCHF , âCH F or âCF ; or R and R , together with the carbon to which they are attached, form an alkylene ring; or R and R together are O; R is R or âOH; and the remaining variables are as defined in the specification, methods of treating diseases susceptible to treatment with neurokinin antagonists with said compounds, and pharmaceutical compositions comprising said compounds are disclosed. Also disclosed are pharmaceutical compositions comprising an effective amount of a compound of claim 1, at least one pharmaceutically acceptable carrier, and in combination with an effective amount of a selective serotonin reuptake inhibitor.

6720329, Apr 13, 2004

Mar 12, 2002

10/096804

Gregory R. Ott - Media PA
Xiao Tao Chen - Newark DE
Jingwu Duan - Newark DE
Matthew E. Voss - Lincoln University PA

Bristol-Myers Squibb Pharma - Princeton NJ

A61K 31443

514278, 514342, 514339, 514336, 546 15, 546152, 5462681, 5462764, 5462797, 5462817

The present application describes novel spiro-cyclic -amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF- converting enzyme (TACE), and/or aggrecanase inhibitors.

6962938, Nov 8, 2005

Dec 18, 2003

10/741326

Gregory R. Ott - Media PA, US
Xiao Tao Chen - Furlong PA, US
Jingwu Duan - Yardley PA, US
Matthew E. Voss - Lincoln University PA, US

Bristol-Myers Squibb Pharma Company - Princeton NJ

A61K031/403
A61K031/38
C07D327/04
C07D207/04
C07D207/18

514409, 514438, 514462, 549 30, 549200, 549300, 549322, 549337, 549341, 548407

The present application describes novel spiro-cyclic β-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-α converting enzyme (TACE), and/or aggrecanase inhibitors.

7160856, Jan 9, 2007

Jul 25, 2002

10/205021

Samuel J. Danishefsky - Englewood NJ, US
Dalibor Sames - New York NY, US
Samuel Hintermann - Basel, CH
Xiao Tao Chen - Newark DE, US
Jacob B. Schwarz - Ann Arbor MI, US
Peter Glunz - Wilmington DE, US
Philip O. Livingston - New York NY, US
Scott Kuduk - Harleyville PA, US
Lawrence Williams - New York NY, US

Sloan-Kettering Institute for Cancer Research - New York NY

A61K 38/14
A61K 39/385
C07K 9/00

514 8, 4241851, 4241941, 4242771, 530322

The present invention provides novel α-O-linked glycoconjugates such as α-O-linked glycopeptides, as well convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin motif commonly found on epithelial tumor cell surfaces. The present invention further provides compositions and methods of treating cancer using the α-O-linked glycoconjugates.

7354922, Apr 8, 2008

Dec 1, 2005

11/291363

Dong Xiao - Warren NJ, US
Anandan Palani - Bridgewater NJ, US
Cheng Wang - Summit NJ, US
Xianhai Huang - Warren NJ, US
Sapna S. Shah - Jamesburg NJ, US
Ashwin U. Rao - Avenel NJ, US
Xiao Chen - Edison NJ, US
Sunil Paliwal - Monroe Township NJ, US
Neng-Yang Shih - Warren NJ, US

Schering Corporation - Kenilworth NJ

A01N 43/58
A01N 43/60
C07D 245/00
C07D 241/36
C07D 471/00

514249, 540460, 544349

A compound having the general structure shown in Formula (I):.

7511062, Mar 31, 2009

May 16, 2005

11/130359

Rongze Kuang - Green Brook NJ, US
David Blythin - North Caldwell NJ, US
Neng-Yang Shih - Warren NJ, US
Xiao Chen - Edison NJ, US
Jianhua Cao - Edison NJ, US
Danlin Gu - Kirkland WA, US
Ying Huang - Berkeley Heights NJ, US
John H. Schwerdt - Lake Hiawatha NJ, US
Pauline C. Ting - New Providence NJ, US
Li Xiao - Cranbury NJ, US

Schering Corporation - Kenilworth NJ

C07D 215/38
A61K 31/44

514312, 514314, 546153, 546159

The invention claims compounds of the formula.

7723342, May 25, 2010

May 11, 2006

11/432133

Anandan Palani - Bridgewater NJ, US
Jing Su - Scotch Plains NJ, US
Dong Xiao - Warren NJ, US
Xianhai Huang - Warren NJ, US
Ashwin U. Rao - Avenel NJ, US
Xiao Chen - Edison NJ, US
Haiqun Tang - Belle Mead NJ, US
Jun Qin - Edison NJ, US
Ying Huang - Berkeley Heights NJ, US
Robert G. Aslanian - Rockaway NJ, US
Brian A. McKittrick - New Vernon NJ, US

Schering Corporation - Kenilworth NJ

C07D 491/052
A61K 31/519
A61P 35/00
A61P 29/00
A61P 3/10
A61P 9/00
A61P 11/00

5142601, 544278

A compound having the general structure of Formula (I):.