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Xiangping Zhu

from Cambridge, MA
Age ~61
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Also known as:
Xiang Ping Zhu, Xiangping Chu, Xingping Zhu, Xianping Zhu, Xingping Cao
Phone and address:
100 Landsdowne St APT 1005, Cambridge, MA 02139
Related to:
Jiajun Zhu, 41Wei ZhuWei-Chu Wang, 64Mingliang Wang, 49Jeffrey Zhu, 25
Connected to:
Abby Zhu, 39Ada Zhu, 31Aileen J Zhu, 31Alyssa H Zhu, 35Ankang Zhu, 65Anwei W Zhu, 49Audrey Zhu, 27Bai C Zhu, 70Bangmin Zhu, 58Bao Y Zhu, 50

Xiangping Zhu Phones & Addresses

  • 100 Landsdowne St APT 1005, Cambridge, MA 02139
  • 20 Valley View Dr, North Grafton, MA 01536 (508) 839-9335
  • Natick, MA
  • Malden, MA
  • Piscataway, NJ
  • New Brunswick, NJ
  • 20 Valley View Dr, North Grafton, MA 01536

Work

Company: Infomass consulting 2008 Position: Principal

Education

Degree: Doctor of Philosophy (Ph.D.) School / High School: Rutgers, The State University of New Jersey-New Brunswick 1998 Specialities: Bioanalytical Chemistry

Skills

Analytical Chemistry • Chromatography • Technology • Sds Page • Mass Spectrometry • Hplc • Lc Ms • Proteomics • Maldi Tof

Industries

Biotechnology

Resumes

Resumes

Xiangping Zhu Photo 1

Vp, Analytical Development And Qc

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Location:
North Grafton, MA
Industry:
Biotechnology
Work:
Infomass Consulting since 2008
Principal
Infomass 2008 - 2012
Consultant
Momenta Pharmaceuticals 2004 - 2008
Principal Scientist and Group Leader
Applied Biosystems 1999 - 2004
Senior Scientist
Able Labs 1998 - 1999
Research Fellow
Education:
Rutgers, The State University of New Jersey-New Brunswick 1998
Doctor of Philosophy (Ph.D.), Bioanalytical Chemistry General Research Institute for Non-ferrours Metals
Master of Science (M.S.), Analytical Chemistry University of Science and Technology of China
BS, Chemistry
Skills:
Analytical Chemistry
Chromatography
Technology
Sds Page
Mass Spectrometry
Hplc
Lc Ms
Proteomics
Maldi Tof

Publications

Us Patents

Methods And Systems For Discovering Protein Modifications And Mutations

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US Patent:
7805253, Sep 28, 2010
Filed:
Aug 31, 2005
Appl. No.:
11/217257
Inventors:
Xunming Chen - Bedford MA, US
Philip J. Savickas - Franklin MA, US
Marvin L. Vestal - Framingham MA, US
Xiangping Zhu - Grafton MA, US
Assignee:
DH Technologies Development Pte. Ltd. - Singapore
International Classification:
G01N 33/48
G01N 31/00
G06G 7/48
US Classification:
702 19, 702 22, 703 11
Abstract:
Accordingly, systems and methods for protein identification are provided. The present teaching provide for a system with one protein identification methodology based on one method and a second protein identification methodology based on a second protein identification methodology to interact and increase confidence in protein identification. Various embodiments employ protein identification methodologies that identify portions of a peptide. Various embodiments provide for a hypothesis generation module that can suggest modifications for the peptide based on differences between experimental and theoretical values. Various embodiments provide for an identifier module that can select one or more hypotheses from the hypothesis module as most probable. In this way, the present teachings can provide for systems and methods to combine protein identification results from multiple protein identification methodologies with the possibility of identifying modifications.

Analysis Of Amino Acid Copolymer Compositions

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US Patent:
7884187, Feb 8, 2011
Filed:
Sep 15, 2010
Appl. No.:
12/882790
Inventors:
Xiangping Zhu - North Grafton MA, US
Zachary Shriver - Cambridge MA, US
Yanjie Jiang - Acton MA, US
Corinne Bauer - Sudbury MA, US
James Eric Anderson - Hudson MA, US
Peter James Ahern - Winchester MA, US
Assignee:
Momenta Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C07K 1/14
US Classification:
530344
Abstract:
Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e. g. , glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard.

Analysis Of Amino Acid Copolymer Compositions

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US Patent:
8329391, Dec 11, 2012
Filed:
Mar 20, 2009
Appl. No.:
12/408058
Inventors:
Xiangping Zhu - North Grafton MA, US
Zachary Shriver - Cambridge MA, US
Yanjie Jiang - Acton MA, US
Corinne Bauer - Sudbury MA, US
James Eric Anderson - Hudson MA, US
Peter James Ahern - Winchester MA, US
Assignee:
Momenta Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C12Q 1/00
C12Q 1/37
A61K 38/00
C07K 2/00
US Classification:
435 4, 435 23, 435 24, 514 11, 514 179, 530300, 530333, 530335, 530336
Abstract:
Methods for analyzing, selecting, characterizing or classifying compositions of a co-polymer, e. g. , glatiramer acetate are described. The methods entail analysis of pyro-glutamate in the composition, and, in some methods, comparing the amount of pyro-glutamate present in a composition to a reference standard. In some cases, the methods entail treating the co-polymer with pyro-glutamate aminopeptidase to cleave N-terminal pyro-glutamate residues.

Methods Related To Cell Surface Glycosylation

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US Patent:
8338088, Dec 25, 2012
Filed:
Apr 15, 2008
Appl. No.:
12/595902
Inventors:
Brian Edward Collins - Arlington MA, US
Carlos J. Bosques - Arlington MA, US
Xiangping Zhu - North Grafton MA, US
Dorota A. Bulik - Malden MA, US
Ian Christopher Parsons - Belmont MA, US
Zachary Shriver - Cambridge MA, US
Rajeev Chillakuru - Cambridge MA, US
Ganesh Venkataraman - Bedford MA, US
Assignee:
Momenta Pharmaceuticals, Inc. - Cambridge MA
International Classification:
C12Q 1/00
US Classification:
435 4
Abstract:
The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.

Methods Of Evaluating Diethylamide In Glatiramer Acetate

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US Patent:
8470603, Jun 25, 2013
Filed:
Apr 30, 2007
Appl. No.:
12/298591
Inventors:
Zachary Shriver - Cambridge MA, US
Ganesh Venkataraman - Bedford MA, US
Jonathan Lansing - Reading MA, US
Corinne Bauer - Sudbury MA, US
Xiangping Zhu - North Grafton MA, US
Assignee:
Momenta Pharmaceuticals, Inc. - Cambridge MA
International Classification:
G01N 24/08
A61K 38/00
US Classification:
436 86, 436173, 530300, 530350
Abstract:
The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e. g. , Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.

Ms Methods To Evaluate Glycans

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US Patent:
8043863, Oct 25, 2011
Filed:
Apr 15, 2008
Appl. No.:
12/595894
Inventors:
Carlos J. Bosques - Arlington MA, US
Nathaniel J. Washburn - Belmont MA, US
Xiangping Zhu - North Grafton MA, US
Ian Christopher Parsons - Belmont MA, US
Assignee:
Momenta Pharmaceuticals, Inc. - Cambridge MA
International Classification:
G01N 24/00
US Classification:
436174, 436173, 702 19, 702 22, 702 23, 702 32
Abstract:
The present disclosure provides, among other things, methods for the identification of sulfated glycans in a mixture of glycans.

Matrix With Noise Reduction Additive And Disposable Target Containing The Same

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US Patent:
20050133715, Jun 23, 2005
Filed:
Dec 21, 2004
Appl. No.:
11/019062
Inventors:
Xiangping Zhu - Grafton MA, US
Ioannis Papayannopoulos - Ashland MA, US
Assignee:
Applied Biosystems - Framingham MA
International Classification:
H01J049/00
US Classification:
250288000
Abstract:
A matrix for mass spectrometry, the matrix comprising an additive that minimizes or eliminates adduct formation and/or chemical noise generation is disclosed. Also disclosed is a method for depositing a matrix on a MALDI target plate and a disposable plate having a dissolvable pre-matrix deposited thereon. The matrix material can be 2,5-dimethoxybenzoic acid and a monobasic or dibasic salt or tribasic salt as an adduct-reducing additive, such as ammonium monobasic phosphate and sulfate salts, dibasic citrate salts and tribasic citrate salts.

Identification Of Modified Peptides By Mass Spectrometry

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US Patent:
20050272164, Dec 8, 2005
Filed:
Apr 13, 2005
Appl. No.:
11/104741
Inventors:
Xiangping Zhu - Grafton MA, US
Stephen Hattan - Roslindale MA, US
Xunming Chen - Bedford MA, US
Ioannis Papayannopoulos - Ashland MA, US
Assignee:
Applera Corporation - Framingham MA
MDS Inc. - Concord
International Classification:
G06F019/00
G01N033/48
G01N033/50
US Classification:
436086000, 702019000
Abstract:
In various aspects, provided are methods for identification of the presence of modified peptides using at least in part mass spectrometric signals from metastable ions that are formed in the field free region of the analyzer. For example, in various embodiments where the modified peptides are phosphopeptides, such metastable ions can appear approximately 95 u lower than the precursor ion m/z value from which they were formed when the peptide contains a phosphate group. In various embodiments, detection of such metastable ions in a MALDI-TOF mass spectrum can identify the modified peptide. In various aspects, provided are methods for identification of the presence of modified peptides using at least in part MS/MS data from two or more of modified peptides, de-modified peptides and non-modified peptides by comparing the sequence and/or site of modification information for two or more of these three forms of a peptide.
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Xiangping Zhu from Cambridge, MA, age ~61 Get Report