Xi Jin Chen

20100204120, Aug 12, 2010

Feb 8, 2010

12/702209

Shibo Jiang - Fresh Meadows NY, US
Zhi Qi - Corona NY, US
Xi Chen - Elmhurst NY, US
Chungen Pan - Guangzho, CN

A61K 38/16
C07K 14/00
A61P 31/18

514 12, 530395

Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.

20120319329, Dec 20, 2012

Apr 20, 2012

13/452441

Xi Chen - New York NY, US

The Trustees of Columbia University in the City of New York - New York NY

B29C 53/02
B29C 59/02

264320, 425352

Self-assembled buckling patterns of thin films on compliant substrates can be used in micro-fabrication. However, most previous work has been limited to planar substrates, and buckling of films on curved substrates has not been widely explored. With the constraining effect from various types of substrate curvature, numerous new types of buckling morphologies can be derived. The morphologies not only enable true three-dimensional (3D) fabrication of microstructures and microdevices, but also can have important implications for the morphogenesis of quite a few natural and biological systems.

20220370633, Nov 24, 2022

Jun 8, 2022

17/835026

- Cambridge MA, US
Xi Chen - West Newton MA, US

Ultivue, Inc. - Cambridge MA

A61K 47/68
G01N 33/58
C07K 16/12
G01N 33/68
C07K 16/42
G01N 33/536

A method for exchange imaging of at least two targets in a sample includes (a) incubating a sample with at least two or more target-recognizing antibodies, each bound to a corresponding monovalent tight antibody binder-docketing moiety (MTAB-DM) reagent capable of binding monovalently to the target-recognizing antibodies, (b) applying at least two imager moieties corresponding to the MTAB-DM, either in series, in batches, or in parallel, and (d) imaging the at least two imager moieties either in series, in batches, or in parallel.

20220239382, Jul 28, 2022

Jan 25, 2022

17/583317

- Espoo, FI
Xi CHEN - Aberdeen NJ, US

H04B 10/69
H04J 14/02
H04B 10/61

An apparatus includes an optical source of an optical wavelength carrier, an optical modulator to receive the optical wavelength carrier, and an optical data receiver. The optical data modulator is configured to produce, from the optical wavelength carrier, an optical signal to carry separate data on different first and second components thereof in individual modulation periods during data transmission and to carry a training sequence on one of the components during time slots for calibration. The first component is relatively phase offset from the second component in the optical signal. The optical data modulator alternates the one of the components between the first and second components over the time slots for calibration. The optical receiver is connected to receive a portion of the optical signal and to temporally interleave a measurement of a characteristic of the first component and a measurement of a characteristic of the second component over the time slots for calibration. The optical receiver is configured to feedback information to the optical data modulator based on the measured characteristics. The optical data modulator is configured to reduce an imbalance between the two components of the optical carrier during data transmission based on the information.

20230058338, Feb 23, 2023

May 10, 2019

16/408659

- New York NY, US
Onur Cakmak - New York NY, US
Xi Chen - New York NY, US

THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY

F03G 7/06
C09J 5/00
C09J 11/00
C08K 11/00

Water-responsive actuators and methods for creating water responsive actuators are disclosed. In some embodiments, the disclosed subject matter includes a first layer, for example a plastic tape, and a second layer, for example bacterial spores and cured adhesive. The second layer can be created in a pattern. The pattern can include joints, which can contract when exposed to dry air and can thereby bend the actuator, and can expand when exposed to humid air and thereby return the actuator its original position.

20230027974, Jan 26, 2023

Jul 8, 2022

17/811486

- Cambridge MA, US
Sarit Agasti - Cambridge MA, US
Xi Chen - Cambridge MA, US
Ralf Jungmann - Cambridge MA, US

President and Fellows of Harvard College - Cambridge MA

C12Q 1/6804
C12Q 1/6818

The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.

20210396760, Dec 23, 2021

Jun 30, 2021

17/363416

- Cambridge MA, US
Xi Chen - West Newton MA, US

Ultivue, Inc. - Cambridge MA

G01N 33/58
G01N 21/64
C07K 16/18
G01N 33/533

An imaging agent comprises (a) at least one target recognition moiety; (b) at least one observable moiety non-transiently bound to the target recognition moiety, and (c) at least one docking moiety bound to the target recognition moiety, wherein the docking moiety is capable of transiently binding at least one observable moiety. In some embodiments, the at least one target recognition moiety is an antibody or antigen binding fragment thereof.

20210032677, Feb 4, 2021

Aug 9, 2018

16/637456

- Boston MA, US
Xi Chen - Newton MA, US

RootPath Genomics, Inc. - Boston MA

C12Q 1/6806
C12Q 1/6869
C12N 15/10

The application provides improved methods of analyzing biological particles and their constituents, including methods of generating truncated and barcoded nucleic acid molecules from at least two target polynucleotide sequences, each from distinct biological particles.