Inventors:
Tian Xu - Guilford CT
Wufan Tao - Branford CT
Weiyi Wang - New Haven CT
Sheng Zhang - New Haven CT
Wan Yu - Guilford CT
Assignee:
Yale University - New Haven CT
International Classification:
A01K 6700
US Classification:
800 13, 536 231, 536 235, 4353201, 435325, 435455
Abstract:
The present invention relates to a tumor suppressor gene, termed large tumor suppressor (lats), and methods for identifying tumor suppressor genes. The method provides nucleotide sequences of lats genes, and amino acid sequences of their encoded proteins, as well as derivatives (e. g. , fragments) and analogs thereof. In a specific embodiment, the lats protein is a human protein. The invention further relates to fragments (and derivatives and analogs thereof) of lats which comprise one or more domains of a lats protein. Antibodies to lats, its derivatives and analogs, are additionally provided. Methods of production of the lats proteins, derivatives and analogs, e. g. , by recombinant means, are also provided. Therapeutic and diagnostic methods and pharmaceutical compositions are provided. The invention also relates to recombinant plants and animals and methods of increasing the growth of edible plants and animals.