William J Henzel

20020192209, Dec 19, 2002

Nov 30, 2001

10/001054

Kevin Baker - Darnestown MD, US
Audrey Goddard - San Francisco CA, US
Austin Gurney - Belmont CA, US
Caroline Hebert - Berkeley CA, US
William Henzel - San Mateo CA, US
Rhona Kabakoff - Pacifica CA, US
David Shelton - Oakland CA, US
Victoria Smith - Burlingame CA, US
Colin Watanabe - Moraga CA, US
William Wood - Hillsborough CA, US

GENENTECH, INC.

A61K039/395
C07H021/04
C12N009/00
C07K016/30
C12P021/02
C12N005/06

424/130100, 536/023200, 435/183000, 435/069100, 435/325000, 435/320100, 530/388800

The present invention concerns methods and compositions for inhibiting neoplastic cell growth. In particular, the present invention concerns antitumor compositions and methods for the treatment of tumors. The invention further concerns screening methods for identifying growth inhibitory, e.g., antitumor compounds. The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

20040018980, Jan 29, 2004

Jun 13, 2003

10/461060

Austin Gurney - Belmont CA, US
Caroline Hebert - Berkeley CA, US
William Henzel - San Mateo CA, US
Rhona Kabakoff - Pacifica CA, US
David Shelton - Oakland CA, US
Daniel Tumas - Orinda CA, US

Genentech, Inc. - South San Francisco CA

A61K038/17

514/012000

The present invention is directed to novel polypeptides, designated FIZZ, which are secreted low molecular weight molecules showing no significant sequence homology to any known protein, and nucleic acid sequences encoding such proteins. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptide of the present invention fused to heterologous polypeptide sequences, and antibodies which bind to the polypeptides of the present invention. Methods of using FIZZ polypeptides to treat various neurotrophin-related conditions are further provided.

62916432, Sep 18, 2001

Jun 5, 1998

9/092508

Hua Zou - Dallas TX
William J. Henzel - San Mateo CA
Xiaodong Wang - Dallas TX

Board of Reports, The University of Texas System - Austin TX
Genentech, Inc. - South San Francisco CA

C07R 1400
C12Q 168
C07H 2100
C12N 1500
C12N 500

530350

Novel polypeptides, designated Apaf-1, which are capable of modulating apoptosis are provided. Compositions including Apaf-1 chimeras, nucleic acid encoding Apaf-1, and antibodies to Apaf-1 are also provided.