William F Blakely

20120329070, Dec 27, 2012

Jun 12, 2007

12/304566

William Blakely - Silver Spring MD, US
Natalia Ossetrova - Sterling VA, US
Marcy Grace - Gaithersburg MD, US
Alexandra Miller - Hyattsville MD, US
Jean M. Muderhwa - San Antonio TX, US
Glen Manglapus - Bel Air MD, US

G01N 33/573
G01N 33/566

435 74, 435 792, 436501

Methods and kits are provided for assessing radiation injury and exposure in a subject. The methods comprise measuring the levels of at least two (2) protein biomarkers from different biological pathways and correlating the levels with an assessment of radiation injury and exposure. Additional use of peripheral blood cell counts and serum enzyme biomarkers, evaluated in the early time frame after a suspected radiation exposure, and use of integrated multiple parameter triage tools to enhance radiation exposure discrimination and assessment are also provided. The information obtained from such methods can be used by a clinician to accurately assess the extent of radiation injury/exposure in the subject, and thus will provide a valuable tool for determining treatment protocols on a subject by subject basis.

20040132037, Jul 8, 2004

Feb 18, 2004

10/469075

Pataje Prasanna - Gaithersburg MD, US
William Blakely - Silver Spring MD, US

C12Q001/68
C12N015/85

435/006000, 435/455000

The present invention provides a simple and rapid method to study chromosome aberrations using unstimulated cells. Premature chromosome condensation is induced by incubating unstimulated cells in the presence of a mitosis-enhancing factor. The condensed chromosomes produced by the present methods can be used in numerous forms of cytogenetic analysis, in particular, with in situ hybridization probes and chromosome painting. This technique can be applied to biological dosimetry of radiation exposures involving uniform whole-body low-linear energy transfer exposures.