Inventors:
Jon P. Miller - Foster City CA
Wesley W. Zmolek - Fremont CA
Assignee:
SRI International - Menlo Park CA
International Classification:
A61K 3170
C07H 1920
Abstract:
Proliferative skin diseases such as psoriasis are treated by topically administering cAMP analogs of the following formula to the afflicted skin site at a dose that preferentially and significantly activates type II protein kinase: ##STR1## where: R. sub. 6 is: (i) --NR. sub. 1 R. sub. 2 where R. sub. 1 and R. sub. 2 are independently selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, and cyclopentyl or are joined together with the nitrogen atom to form a hetrocyclic group having 4 to 5, inclusive, annular carbon atoms with the proviso that the total number of carbon atoms in the --NR. sub. 1 R. sub. 2 group is 4 or 5, or (ii) --XR where X is a chalcogen atom of atomic number 8 or 16 and R is alkyl of 4 or 5 carbon atoms, R. sub. 8 is: (i) --X--(CH. sub. 2). sub. n R. sub. 3 where X is defined previously, n is an integer in the range of 1 to 3, inclusive, R. sub.