Wen Z Li

6518421, Feb 11, 2003

Feb 1, 2001

09/775361

Wen Sen Li - Holmdel NJ
John E. Thornton - Newtown PA
Zhenrong Guo - East Brunswick NJ
Shankar Swaminathan - Monmouth Junction NJ

Bristol-Myers Squibb Company - Princeton NJ

C07D49100

540462, 548181

The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.

RE39356, Oct 17, 2006

Feb 11, 2005

11/056606

Wen Sen Li - Holmdel NJ, US
John E. Thornton - Newtown PA, US
Zhenrong Guo - East Brunswick NJ, US
Shankar Swaminathan - Monmouth Junction NJ, US
Robert M. Borzilleri - New Hope PA, US
Soong-Hoon Kim - Titusville NJ, US
Denis Favreau - St. Hubert, CA

Bristol-Myers Squibb Co. - Princeton NJ

C07D 491/00
C07D 417/00

540462, 548181, 548204

The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.

20030004338, Jan 2, 2003

Sep 5, 2001

09/946721

Wen Li - Holmdel NJ, US
John Thornton - Newtown PA, US
Zhenrong Guo - East Brunswick NJ, US
Shankar Swaminathan - Monmouth Junction NJ, US

C07D225/00

540/461000, 554/078000, 554/103000

The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.