US Patent:
20030157110, Aug 21, 2003
Inventors:
Wenqian An - Framingham MA, US
Hong Chen - Newton MA, US
Assignee:
Millennium Pharmaceuticals, Inc.
International Classification:
A61K048/00
C12Q001/68
G01N033/53
G01N033/567
A61K039/395
US Classification:
424/146100, 514/044000, 435/006000, 435/007200
Abstract:
The invention relates to methods and compositions for the diagnosis and treatment of metabolic disorders, including, but not limited to, obesity, overweight, diabetes, insulin resistance, anorexia, and cachexia. The invention further provides methods for identifying a compound capable of treating a metabolic disorder. The invention also provides methods for identifying a compound capable of modulating a metabolic activity. Yet further, the invention provides a method for modulating a metabolic activity. In addition, the invention provides a method for treating a subject having a metabolic disorder characterized by aberrant MMP-12 polypeptide activity or aberrant MMP-12 nucleic acid expression. In another aspect, the invention provides methods for modulating lipogenesis in a subject and methods for modulating lipolysis in a subject.