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Wendell Wierenga

from Kalamazoo, MI
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Related to:
Karl A Schneider, 74Janelle R Wierenga, 49Melissa BoltBarton H Bolt, 54Melissa J Bolt, 51Pamela S Wierenga, 76
Connected to:
Cheryl A Wierenga, 72Danielle Wierenga, 38Jonathan J Wierenga, 37Judson J Wierenga, 49Laura M Wierenga, 59Phillip Wierenga, 70Suzanne P Wierenga, 58Thomas D Wierenga, 45William J Wierenga, 54Rhoda M Wierer, 73

Wendell Wierenga Phones & Addresses

  • Kalamazoo, MI

Publications

Us Patents

Process For Therapeutic Treatment

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US Patent:
45902119, May 20, 1986
Filed:
May 30, 1984
Appl. No.:
6/615661
Inventors:
John J. Voorhees - Ann Arbor MI
Wendell Wierenga - Kalamazoo MI
Assignee:
The Upjohn Company - Kalamazoo MI
Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 3117
US Classification:
514594
Abstract:
This invention relates to a new method of therapy comprising the administration of a pro-drug to a human or animal, said pro-drug being a compound formed by a therapeutic compound chemically combined with another moiety by a photocleavable bond and irradiating the diseased area with ultraviolet radiation in an amount sufficient to cleave the bond and release the therapeutic compound in a therapeutically effective amount. Specifically disclosed are pro-drugs which are cleaved to therapeutically active medications which are anti-proliferative and anti-inflammatory compounds and the treatment of inflammatory and/or proliferative skin diseases therewith.

1,2,8,8A-Tetrahydrocyclopropa(C)Pyrrolo(3,2-E)-Indol-4-(5H)-Ones And Related Compounds

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US Patent:
49122274, Mar 27, 1990
Filed:
Aug 7, 1986
Appl. No.:
6/894314
Inventors:
Robert C. Kelly - Augusta MI
Martha A. Warpehoski - Kalamazoo MI
Wendell Wierenga - Kalamazoo MI
Assignee:
The Upjohn Company - Kalamazoo MI
International Classification:
C07D48708
US Classification:
548421
Abstract:
1,2,8,8a-Tetrahydrocyclopropa[3]pyrrolo(3,2-e)indol-4(5H)-ones, and related compounds of formulas I and intermediate therefor II ##STR1## wherein R. sub. 2, R. sub. 2 ', R. sub. 3, R. sub. 5, R. sub. 50 and X are as defined in the specification, e. g. , (7bR,8aS)-1,2,8,8a-tetrahydro-7-methyl-2-[[5-(((1H-indol-2-yl)carbonyl)ami no)-1H-indol-2-yl]carbonyl]cyclopropa[pyrrolo[3,2-e]indol-4(5H)-one (U-71,184), as purified, and its racemic form (U-68,415), and related compounds, are useful as ultraviolet light absorbers and as antibacterials. The lead compounds are useful as antitumor drug compounds in standard laboratory animal tests.

Process For Therapeutic Treatment

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US Patent:
43024564, Nov 24, 1981
Filed:
Aug 4, 1980
Appl. No.:
6/174990
Inventors:
John J. Voorhees - Ann Arbor MI
Wendell Wierenga - Kalamazoo MI
Assignee:
The Upjohn Company - Kalamazoo MI
The Regents of the University of Michigan - Ann Arbor MI
International Classification:
A61K 31705
A61K 31505
C07J 4100
US Classification:
424251
Abstract:
This invention relates to a new method of therapy comprising the administration of a pro-drug to a human or animal, said pro-drug being a compound formed by a therapeutic compound chemically combined with another moiety by a photocleavable bond and irradiating the diseased area with ultraviolet radiation in an amount sufficient to cleave the bond and release the therapeutic compound in a therapeutically effective amount. Specifically disclosed are pro-drugs which are cleaved to therapeutically active medications which are anti-proliferative and anti-inflammatory compounds and the treatment of inflammatory and/or proliferative skin diseases therewith.

Process For Treating Hypertension

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US Patent:
43082726, Dec 29, 1981
Filed:
Oct 3, 1980
Appl. No.:
6/193573
Inventors:
Wendell Wierenga - Kalamazoo MI
Harvey I. Skulnick - Kalamazoo MI
Assignee:
The Upjohn Company - Kalamazoo MI
International Classification:
A61K 31505
US Classification:
424251
Abstract:
A process for treating hypertension comprising the systemic administering to a hypertensive subject a compound of the formula: ##STR1## wherein R. sub. 1 is --NH. sub. 2. R. sub. 2 is chloro, bromo, or iodo. R. sub. 3 is hydrogen or fluorine. R. sub. 4 is hydrogen or fluorine, and R. sub. 5 is hydrogen, fluorine, or CH. sub. 3 ; or the salts thereof in association with a pharmaceutical carrier.

1,2,8,8A-Cyclopropa?c!Benzo?1,2,-B:-4,3-B'!Dipyrrol-4(5H)-Ones

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US Patent:
44243650, Jan 3, 1984
Filed:
Jun 22, 1982
Appl. No.:
6/391055
Inventors:
Wendell Wierenga - Kalamazoo MI
Assignee:
The Upjohn Company - Kalamazoo MI
International Classification:
C07C48702
A01N 4338
US Classification:
548421
Abstract:
Novel antibacterially active compound, 1,2,8,8a-cyclopropa�c!benzo�1,2-b:-4,3-b'!dipyrrol-4(5H)-one, prepared by a novel chemical process. This compound, as well as antibacterially-active intermediates, can be used to eradicate or control susceptible bacteria, for example B. subtilis, K. pneumonia, S. lutea, S. aureus, and M. avium.

Substituted Alkoxy Carbonyl-3-Oxo-.Alpha.-Phthalimido-5-Isoxozolidineacetic Acids

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US Patent:
42752140, Jun 23, 1981
Filed:
Jul 31, 1979
Appl. No.:
6/062459
Inventors:
Robert C. Kelly - Kalamazoo MI
Wendell Wierenga - Kalamazoo MI
Assignee:
The Upjohn Company - Kalamazoo MI
International Classification:
C07D41306
C07D26104
US Classification:
548243
Abstract:
Analogs of tricholomic acids and process for preparing them.

Processes For The Preparation Of 6-Aryluracils

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US Patent:
45784663, Mar 25, 1986
Filed:
Sep 17, 1984
Appl. No.:
6/651495
Inventors:
Harvey I. Skulnick - Kalamazoo MI
Herman W. Smith - Kalamazoo MI
Robert J. Smith - Kalamazoo MI
Wendell Wierenga - Kalamazoo MI
Assignee:
The Upjohn Company - Kalamazoo MI
International Classification:
C07D23910
C07D26506
US Classification:
544309
Abstract:
This invention relates to the use of 6-aryluracils as antiinflammatory and antiarthritic agents and also to both novel intermediates and novel processes for the preparation of selected 6-aryluracils.

Process For Therapeutic Treatment

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US Patent:
42358876, Nov 25, 1980
Filed:
Apr 13, 1977
Appl. No.:
5/787230
Inventors:
John J. Voorhees - Ann Arbor MI
Wendell Wierenga - Kalamazoo MI
Assignee:
The Upjohn Company - Kalamazoo MI
International Classification:
A61K 31705
C07J 4100
US Classification:
424180
Abstract:
This invention relates to a new method of therapy comprising the administration of a pro-drug to a human or animal, said pro-drug being a compound formed by a therapeutic compound chemically combined with another moiety by a photocleavable bond and irradiating the diseased area with ultraviolet radiation in an amount sufficient to cleave the bond and release the therapeutic compound in a therapeutically effective amount. Specifically disclosed are pro-drugs which are cleaved to therapeutically active medications which are anti-proliferative and anti-inflammatory compounds and the treatment of inflammatory and/or proliferative skin diseases therewith.
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Wendell Wierenga from Kalamazoo, MI Get Report