Wei A Qian

7778301, Aug 17, 2010

Jun 25, 2008

12/215158

Mostafa A. El-Sayed - Atlanta GA, US
Wei Qian - Marietta GA, US
Qusai Darugar - Houston TX, US

Georgia Tech Research Corporation - Atlanta GA

H01S 3/14
H01S 3/20

372 51, 372 39

Disclosed is a lasing complex comprising a room temperature solution containing cadmium sulfide (CdS) quantum dots. Optical gain has been observed in CdS nanocrystal quantum dots in strong confinement regime in toluene solution at room temperature using femtosecond transient absorption techniques. The optical gain lifetime is measured to be 20 picoseconds under pump fluence of 0. 77 mJ/cm. The relative lower gain threshold compared to that of CdSe quantum dots is attributed to the long lifetime of fluorescence and biexcitons and the relatively sharp photoluminescence linewidth. The CdS nanocrystals are excellent gain media for semiconductor quantum dot based blue lasers.

20120225021, Sep 6, 2012

Mar 2, 2011

13/038788

Wei QIAN - Ann Arbor MI, US
Makoto MURAKAMI - Ann Arbor MI, US
Yuki ICHIKAWA - Ann Arbor MI, US
Yong CHE - Ann Arbor MI, US

A61K 9/14
A61K 49/00
A61K 33/24
C12Q 1/00
A61K 39/395
G01N 33/53
G01N 21/64
G01N 21/62
A61P 35/00
G01N 21/75
A61K 38/43
B82Y 40/00
B82Y 5/00
B82Y 15/00

424 96, 436166, 424 91, 424649, 424400, 435 4, 4241781, 424 941, 436164, 436501, 436172, 436171, 977773, 977906, 977915, 977927, 977904, 977840

In the present invention, a method of producing stable bare colloidal gold nanoparticles is disclosed. The nanoparticles can subsequently be subjected to partial or full surface modification. The method comprises preparation of colloidal gold nanoparticles in a liquid by employing a top-down nanofabrication method using bulk gold as a source material. The surface modification of these nanoparticles is carried out by adding one or multiple types of ligands each containing functional groups which exhibit affinity for gold nanoparticle surfaces to produce the conjugates. Because of the high efficiency and excellent stability of the nanoparticles produced by this method, the fabricated gold nanoparticle conjugates can have surface coverage with functional ligands which can be tuned to be any percent value between 0 and 100%.

20120242987, Sep 27, 2012

Mar 22, 2012

13/426775

Bing LIU - Ann Arbor MI, US
Wei QIAN - Ann Arbor MI, US
Makoto MURAKAMI - Ann Arbor MI, US
Yong CHE - Ann Arbor MI, US

IMRA AMERICA, INC. - Ann Arbor MI

G01J 3/44
B05D 3/06
B05D 7/22
B82Y 40/00
B82Y 30/00

356301, 427596, 427597, 4273831, 977773, 977889

An apparatus for performing surface-enhanced Raman scattering (SERS) is disclosed wherein an inner surface of a container is coated with SERS active materials such as nanoparticles of noble metals. Such a container can provide a partially enclosed, optical diffuse cavity whose inner surfaces serve for dual purposes of enhancing Raman scattering of the contained analyte and optical integration, therefore improving the efficiency of optical excitation and signal collection. The container may be configured to isolate the SERS active material from the external environment. The container, which may be a cylindrical tube, may be referred to as a SERS tube. Methods of coating the inner wall of a container with pulsed laser ablation and with nanoparticle colloids, respectively, are disclosed.

20130189793, Jul 25, 2013

Jan 18, 2013

13/744633

Wei Qian - Ann Arbor MI, US
Yong Che - Ann Arbor MI, US

G01N 21/64

436172

In the present invention, a method for determining the stability threshold amount of a stabilizer component for gold nanoparticles to prevent their aggregation in any electrolyte solution, is disclosed. The method permits for very low levels of stabilizer components to be used while still permitting conjugation with other functional ligands. The method comprises preparation of stable gold nanoparticles conjugated with different amount of stabilizing agents in deionized water first and then testing the stability of colloidal suspension of these gold nanoparticles in the presence of the electrolyte solution by monitoring the absorbance at 520 nm. The invention also comprises a method for fabrication of nanoconjugates comprising gold nanoparticles and only the stabilizer components or comprising gold nanoparticles, stabilizer components and functional ligands, which are stable in the presence of electrolytes.

20130243874, Sep 19, 2013

Mar 4, 2013

13/783563

Masayuki Ito - Cupertino CA, US
Wei Qian - Ann Arbor MI, US
Yong Che - Ann Arbor MI, US

IMRA of America, Inc. - Ann Arbor MI
The Regents of the University of Michigan - Ann Arbor MI

A61K 47/02
A61K 9/14
G01N 21/47

424497, 436501, 2524081, 424649

The present provides amphiphilic block copolymer coated surfaces (e.g., nanoparticles, medical devices, etc.) and methods of preparing such surfaces. In certain embodiments, the present invention provides amphiphilic block copolymer coated single dispersed nanoparticles, which are stable in buffer (e.g., PBS) and have neutral but functionable surfaces, and methods of preparing the same.

20160090446, Mar 31, 2016

Dec 8, 2015

14/962619

- Ann Arbor MI, US
Wei Qian - Ann Arbor MI, US
Yong Che - Ann Arbor MI, US
Masayuki Ito - Cupertino CA, US
Hayley Paholak - Ann Arbor MI, US

C08G 65/48

The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic).

20140296551, Oct 2, 2014

Mar 14, 2014

14/212594

- Ann Arbor MI, US
Wei Qian - Ann Arbor MI, US
Yong Che - Ann Arbor MI, US
Masayuki Ito - Cupertino CA, US
Hayley Paholak - Ann Arbor MI, US

The Regents of the University of Michigan - Ann Arbor MI
IMRA of America, Inc. - Ann Arbor MI

C08G 65/48

556113

The present invention relates to methods, compositions, and kits for generating conjugated gold nanoparticles. In certain embodiments, the present invention provides methods of generating unsaturated conjugated gold nanoparticles by mixing naked gold nanoparticles with a first type of attachment molecules at a molar ratio such that the attachment molecules attach to the naked gold particles at a density level below the saturation level of the naked gold particles (e.g., at a saturation level of 1-99%). In some embodiments, a second type of attachment molecules (e.g., with the opposite charge as the first type of attachment molecules) are mixed with the unsaturated conjugated gold nanoparticles to generate double-conjugated gold nanoparticles (e.g., that are zwitterionic)

20140213807, Jul 31, 2014

Jan 23, 2014

14/161773

Yuki Ichikawa - Kariya, JP
Andrius Marcinkevicus - Saline MI, US
Masayuki Ito - Cupertino CA, US
Wei Qian - Ann Arbor MI, US

C08G 65/328
B82Y 30/00

556112, 252 622, 422105, 264400

The present disclosure is directed to methods of preparing stable suspensions of precious metal nanoparticles and methods for attaching bio-molecules to the nanoparticles. The formation of nanoparticles can be accomplished by either chemical synthesis or pulsed laser ablation in a liquid. The present disclosure reveals the importance of controlling the conductivity of the dispersion medium during pulsed laser ablation in a liquid to control the particle size of the nanoparticles. The present disclosure also reveals the importance of adjusting and maintaining the conductivity in a range of 25 μS/cm or less during storage of the nanoparticles and just prior to performing bioconjugation reactions. The control of conductivity is an important process for maintaining the nanoparticles as a stable non-aggregated colloidal suspension in a dispersion medium.