Warren Bennett Stern

8222267, Jul 17, 2012

Jul 18, 2011

13/185016

Patricia T. Richards - West New York NJ, US
Warren C. Stern - Plymouth MA, US
Benjamin Schwartz - St. Louis MO, US

QRxPharma Ltd. - North Sydney

A01N 43/42
A01N 43/38
A01N 37/10
A61K 31/44
A61K 31/40
A61K 31/19
A61K 9/28
A61K 9/20
C07D 489/00

514282, 546 44, 514420, 514568, 424474, 424468

A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents, a one-hour average oral morphine equivalents, or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.

20060100263, May 11, 2006

Oct 31, 2005

11/263045

Anthony Basile - Hoboken NJ, US
Warren Stern - Plymouth MA, US

A61K 31/403

514412000

Methods and compositions containing bicifadine are provided for the treatment and prevention of hyperthermia in mammalian subjects. The methods and compositions may be used to prevent or treat fever, pyresis, menopausal hot flashes; peri menopausal hot flashes, postmenopausal hot flashes, hot flashes caused by anti-estrogen therapy, hot flashes secondary to surgical removal of estrogen producing tissue, hot flashes caused by radiation therapy, malignant hyperthermia, serotonin syndrome, heat stroke, febrile seizures, and neuroleptic malignant syndrome, among other conditions. Additional compositions and methods are provided employing bicifadine to treat pyresis and simultaneously elicit an analgesic response in mammalian subjects. Yet additional compositions and methods are provided which employ bicifadine in combination with a second antipyretic agent, a second analgesic agent, or a different therapeutic agent to yield more effective antipyretic treatment tools, and/or dual activity therapeutic methods and formulations useful to prevent or reduce hyperthermia and one or more additional symptoms (e.g., pain, or depression) in mammalian subjects.

20080014272, Jan 17, 2008

Jul 10, 2007

11/775721

Phil Skolnick - Edgewater NJ, US
Warren Stern - Plymouth MA, US

A61K 31/403
A61K 31/19
A61K 31/44
A61K 9/00
A61P 19/00
A61P 19/02

424484000, 514282000, 514415000, 514557000

The present invention relates to methods, pharmaceutical compositions and kits for treating osteoarthritis associated pain, inflammation and improving function in a patient comprising a first therapeutic agent which comprises bicifadine or a pharmaceutically acceptable salt, enantiomer, solvate, hydrate, polymorph or prodrug thereof and a second therapeutic agent which comprises a non-steroidal anti-inflammatory drug or derivative thereof.

20080027119, Jan 31, 2008

Oct 26, 2005

11/260887

Arnold Lippa - New York NY, US
Warren Stern - Plymouth MA, US
Janet Codd - Westmeath, IE
Brian Boland - KIldare, IE
Lim Johnson - Edison NJ, US

A61K 31/403
A61P 25/00

514412000

Methods and compositions are provided for formulating and administering bicifadine and related compounds to treat acute pain, chronic pain, and symptoms associated with neuropathic disorders.

20130345280, Dec 26, 2013

Jun 2, 2013

13/907920

Arnold S. Lippa - New York NY, US
Warren Stern - Plymouth MA, US
Janet Codd - Westmeath, IE
Brian Boland - Laragh, IE
Johnson Lim - Edison NJ, US

A61K 9/20
A61K 31/403

514412

Methods and compositions are provided for formulating and administering bicifadine and related compounds to treat or prevent functional impairment and disabilities associated with acute pain, chronic pain, and neuropathic disorders.