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Vladimir B Birman

from Saint Louis, MO
Age ~55

Vladimir Birman Phones & Addresses

  • 1567 Swallow Dr, Saint Louis, MO 63144 (314) 962-7843
  • Brentwood, MO
  • Brooklyn, NY
  • 5637 Maryland Ave, Chicago, IL 60637 (773) 643-0636
  • Charlotte, NC

Publications

Us Patents

Total Synthesis Of Merrilactone A

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US Patent:
20040006121, Jan 8, 2004
Filed:
Dec 13, 2002
Appl. No.:
10/318777
Inventors:
Samuel Danishefsky - Englewood NJ, US
Vladimir Birman - New York NY, US
International Classification:
A61K031/497
A61K031/4439
A61K031/4433
A61K031/407
A61K031/365
C07D491/02
US Classification:
514/410000, 514/468000, 548/421000, 549/298000, 514/255050, 514/338000, 544/405000, 546/276700, 546/284100
Abstract:
This invention provides a total synthesis of Merrillactone and Merrilactone analogues having the structure wherein Z is O or N—X, where X is H, straight or branched substituted or unsubstituted alkyl, alkenyl or alkynyl, or acyl, carbamoyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, aralkyl, amino, alkyl amino, or dialkyl amino; wherein each of Rand Ris H or Rand Rtogether are O; wherein each of Rand Ris H or Rand Rtogether are O; wherein each of Rand Ris, independently, H, alkyl, aralkyl, or aryl; wherein each of Rand Ris, independently, H or OR, where Ris alkyl or —C(O)—R, where Ris H, —CHR, —CHRR, —CRRR, —OR, alkenyl or alkynyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, aralkyl, amino, alkyl amino, or dialkyl amino, wherein each Ris straight or branched, substituted or unsubstituted alkyl, alkenyl or alkynyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, aralkyl, or amino; and wherein Ris straight or branched, unsubstituted alkyl, alkenyl or alkynyl, cycloalkyl, aryl, heterocycloalkyl, heteroaryl, aralkyl, or amino, or wherein Rand Rtogether are O; wherein each of Rand Ris, independently, H, alkyl, OH, or OR, where Ris an alkyl, an acyl, or an amide, or Rand Rtogether are CH, or wherein Rand Rtogether are O; wherein if one of Ror Rand one of Ror Ris absent, a double bond is formed as indicated by the broken line; and wherein each of Rand Ris, independently, H, OH, or OR, where Ris an alkyl, an acyl, or an amide, or Rand Rtogether are O, or wherein Rand Rtogether are O, including intermediates in the synthesis.

Enantioselective Acyl Transfer Catalysts And Their Use In Kinetic Resolution Of Alcohols And Desymmetrization Of Meso-Diols

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US Patent:
20050256150, Nov 17, 2005
Filed:
Feb 22, 2005
Appl. No.:
11/062683
Inventors:
Vladimir Birman - Brentwood MO, US
International Classification:
A61K031/4745
C07D471/04
US Classification:
514292000, 514303000, 546094000, 546118000
Abstract:
Novel enantioselective acylation catalysts comprising chiral derivatives of DHIP and DHIQ, having the following representative general structures are disclosed: These new compounds are useful for resolving racemates or further enhancing the enantiomeric excess of an enantiomerically enriched composition and for desymmetrizing meso compounds.

Enantioselective Synthesis Of Merrilactone And Its Analogs

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US Patent:
20090131498, May 21, 2009
Filed:
Jan 18, 2006
Appl. No.:
11/795705
Inventors:
Samuel J. Danishefsky - Englewood NJ, US
Zhaoyang Meng - New York NY, US
Vladimir Birman - Brentwood MO, US
International Classification:
A61K 31/365
C07D 493/02
C07D 491/02
C07C 69/757
C07C 49/573
A61P 25/00
C07D 303/02
C07D 307/93
C07D 409/02
A61K 31/407
US Classification:
514410, 549298, 549297, 548421, 560120, 568379, 549545, 549459, 549465, 549 22, 514468
Abstract:
This invention provides a method of synthesizing enantioenriched merrilactone A and enantiopure merrilactone A, as well as an improved method of synthesizing racemic merrilactone. This invention also provides intermediate compounds and methods of treating peripheral neuropathies
Vladimir B Birman from Saint Louis, MO, age ~55 Get Report