US Patent:
20160311919, Oct 27, 2016
Inventors:
- Needham MA, US
- Fremont CA, US
Meina Liang - Fremont CA, US
Orit Foord - Foster City CA, US
Scott Klakamp - Fremont CA, US
Kam Fai Tse - Clinton CT, US
Vincent A. Pollack - Gales Ferry CT, US
Luca Rastelli - Guilford CT, US
John Herrmann - Bothell WA, US
Henri Lichenstein - Guilford CT, US
Michael E. Jeffers - Branford CT, US
William J. LaRochelle - Madison CT, US
Gulshan Ara - Harrisburg PA, US
Peter Mezes - Old Lyme CT, US
Andrei Chapoval - Towson MD, US
Cyrus Karkaria - Branford CT, US
Michael Torgov - Middletown CT, US
Juan Davagnino - Madison CT, US
International Classification:
C07K 16/30
C07K 16/28
A61K 47/48
Abstract:
The present invention provides fully human monoclonal antibodies that specifically bind to GPNMB, and uses thereof. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs) are provided. The present invention also provides immunoconjugates comprising anti-GPNMB antibodies and methods of using such immunoconjugates. The present invention further provides bi-specific antibodies comprising an anti-GPNMB antibody component and an anti-CD3 component, and methods of using such bispecific antibodies.