US Patent:
20200368300, Nov 26, 2020
Inventors:
- Durham NC, US
Matthias Gromeier - Durham NC, US
Smita Nair - Durham NC, US
Vidyalakshmi Chandramohan - Durham NC, US
Assignee:
Duke University - Durham NC
International Classification:
A61K 35/768
A61K 39/13
A61K 39/395
A61P 35/00
C07K 16/28
C12N 7/00
C12N 15/85
A61K 39/39
A61K 9/127
Abstract:
Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. Combination with immune checkpoint inhibitors increases the anti-tumor effect. Tumors of different types are susceptible to the combination treatment, including but not limited to melanoma, glioglastoma, renal cell carcinoma, prostate cancer, breast cancer, lung cancer, medulloblastoma, and colorectal cancer.