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Victor Ginsburg Phones & Addresses

  • 6905 Loch Lomond Dr, Bethesda, MD 20817 (301) 229-6694

Publications

Us Patents

Carbohydrate Receptor For Bacteria And Method For Use Thereof

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US Patent:
53895215, Feb 14, 1995
Filed:
Jan 13, 1993
Appl. No.:
8/003915
Inventors:
Howard C. Krivan - Rockville MD
Victor Ginsburg - Bethesda MD
David D. Roberts - Rockville MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
International Classification:
G01N 33569
US Classification:
435 733
Abstract:
The invention is a method for detecting pathogenic bacteria by specific binding of the bacteria to GalNAc. beta. 1-4Gal sequences found in fucosyl-asialo GM1, asialo GM1 and asialo GM2. An agglutination reaction is disclosed comprising contacting a culture suspected of containing the bacteria with a suspension of a purified carbohydrate compound bound to an insoluble carrier and detecting the presence of perceptible agglutination of the carrier as an indication of the presence of the bacteria. Bacteria which can be detected using the claimed method include Pseudomonas, Haemophilus, Staphylococcus, Klebsiella and Streptococcus pneumoniae.

Carbohydrate Receptor For Bacteria And Method For Use Thereof

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US Patent:
53860276, Jan 31, 1995
Filed:
May 13, 1993
Appl. No.:
8/060134
Inventors:
Howard C. Krivan - Rockville MD
Victor Ginsburg - Bethesda MD
David D. Roberts - Rockville MD
Assignee:
The United States of America as represented by the Department of Health
& Human Services - Washington DC
International Classification:
C08B 3700
A61K 3902
US Classification:
5361231
Abstract:
A carbohydrate receptor for pathogenic bacteria is a purified carbohydrate compound that is a member selected from the group consisting of fucosyl-asialo GM1, asialo GM1, and asialo GM2. The receptor can be included in a composition having a pharmaceutically acceptable carrier. The receptor may be used for purifying, detecting, or removing bacteria from diseased tissue. The structure of the receptor is N-acetylagalctosamine-beta-1-4-galactose-beta-1-4-glucose, abbreviated GalNAc. beta. 1-4Gal. beta. 1-4Glc. The receptor is present in human and animal tissues as complex molecule and can serve as the attachment site for bacterial infection. For example, fucosyl-asialo GM1, asialo GM1, and asialo GM2 are three biological molecules which occur in cell membranes and contain the carbohydrate receptor.

Receptor For Pathogenic Fungi

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US Patent:
52428001, Sep 7, 1993
Filed:
Jan 30, 1990
Appl. No.:
7/472128
Inventors:
Victor E. Jimenez - Bethesda MD
Victor Ginsburg - Bethesda MD
Howard C. Krivan - Rockville MD
Assignee:
The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC
International Classification:
G01N 3353
G01N 33569
US Classification:
435 72
Abstract:
A glycolipid receptor that specifically binds pathogenic fungi has been identified. Various properties and utilities of the receptor have been described.

Diagnostic Kit And Diagnostic Method Utilizing Carbohydrate Receptors

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US Patent:
52253309, Jul 6, 1993
Filed:
Oct 5, 1989
Appl. No.:
7/417691
Inventors:
Victor Ginsburg - Bethesda MD
Howard C. Krivan - Rockville MD
David D. Roberts - Rockville MD
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
International Classification:
G01N 33569
G01N 3353
US Classification:
435 732
Abstract:
A diagnostic kit for detecting the presence of microorganisms, comprising an insoluble substrate; and a carbohydrate receptor immobilized on the insoluble substrate, the carbohydrate receptor being capable of adsorbing microorganisms; and a labelled reagent useful for detecting the presence of microorganisms bound to the carbohydrate receptors and a method for detecting the presence of specified microorganisms in a sample, which comprises contacting a sample to be tested with carbohydrate receptors immobilized on an insoluble substrate; and determining the extent of binding of microorganisms in the sample to the carbohydrate receptors by use of a labelled reagent.

Diagnostic Kit And Diagnostic Method For Mycoplasma Utilizing Carbohydrate Receptors

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US Patent:
55299040, Jun 25, 1996
Filed:
Jun 21, 1993
Appl. No.:
8/079387
Inventors:
Victor Ginsburg - Bethesda MD
Howard C. Krivan - Santa Barbara CA
David D. Roberts - Rockville MD
Assignee:
The United States of America as represented by the Secretary of the
Department of Health and Human Services - Washington DC
International Classification:
G01N 33554
G01N 33569
US Classification:
435 732
Abstract:
A diagnostic kit for detecting the presence of microorganisms, comprising an insoluble substrate; and a carbohydrate receptor immobilized on the insoluble substrate, the carbohydrate receptor being capable of adsorbing microorganisms; and a labelled reagent useful for detecting the presence of microorganisms bound to the carbohydrate receptors and a method for detecting the presence of specified microorganisms in a sample, which comprises contacting a sample to be tested with carbohydrate receptors immobilized on an insoluble substrate; and determining the extent of binding of microorganisms in the sample to the carbohydrate receptors by use of a labelled reagent.

Adhesion Of Mycoplasma Pneumoniae And Mycoplasma Hominus To Sulfatide

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US Patent:
50894790, Feb 18, 1992
Filed:
Nov 28, 1988
Appl. No.:
7/277634
Inventors:
Howard C. Krivan - Rockville MD
Victor Ginsburg - Bethesda MD
David D. Roberts - Rockville MD
International Classification:
A61K 3195
A61K 3170
US Classification:
514 25
Abstract:
The invention is a carbohydrate receptor for Mycoplasma pneumoniae and Mycoplasma hominus and its use to detect mycoplasma in biological fluids and diseased tissue and cells. The receptor can be included in a composition having a pharmaceutically acceptable carrier. Methods are provided for purifying, detecting, or removing mycoplasma from diseased tissue or fluids. The receptor includes sulfatides, dextran sulfate, sialyloligosaccharides, and mixtures thereof.

Isbn (Books And Publications)

Complex Carbohydrates

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Author

Victor Ginsburg

ISBN #

0121818918

Methods in Enzymology: Complex Carbohydrates, Part D

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Author

Victor Ginsburg

ISBN #

0121819833

Complex Carbohydrates

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Author

Victor Ginsburg

ISBN #

0121820386

Complex Carbohydrates

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Author

Victor Ginsburg

ISBN #

0121820807

Biology of Carbohydrates

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Author

Victor Ginsburg

ISBN #

0471039055

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