Venkataraman Bringi

7264951, Sep 4, 2007

May 22, 1998

09/083198

Venkataraman Bringi - Ithaca NY, US
Prakash G. Kadkade - Marlboro MA, US
Christopher L. Prince - Lansing NY, US
Braden L. Roach - Interlaken NY, US

Phyton, Inc. - Ithaca NY

C12P 17/02

435123, 435244, 435420, 435431, 549510, 549511

This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known species, e. g. , and. Particular modifications of culture conditions (i. e. , media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of is particularly enhanced by use of one or more of these conditions, yield of taxanes for all species has been found to benefit from use of these conditions.

8338143, Dec 25, 2012

Dec 17, 2010

12/972064

Venkataraman Bringi - Ithaca NY, US
Prakash Kadkade - Marlboro MA, US
Christopher Prince - Lansing NY, US
Braden Roach - Interlaken NY, US

Phyton Holdings, LLC - San Antonio TX

C12P 17/02

435123, 435244, 435420, 435431, 549510, 549511

This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known species, e. g. , and. Particular modifications of culture conditions (i. e. , media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of is particularly enhanced by use of one or more of these conditions, yield of taxanes for all species has been found to benefit from use of these conditions.

20080108115, May 8, 2008

Aug 9, 2007

11/836604

Venkataraman Bringi - Ithaca NY, US
Prakash Kadkade - Marlboro MA, US
Christopher Prince - Lansing NY, US
Braden Roach - Interlaken NY, US

DFB BIOTECH, INCORPORATED - Fort Worth TX

C12P 17/02

435123000

This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known species, e.g., and Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of is particularly enhanced by use of one or more of these conditions, yield of taxanes for all species has been found to benefit from use of these conditions.

20130017582, Jan 17, 2013

Sep 14, 2012

13/618284

Venkataraman BRINGI - Ithaca NY, US
Prakash G. Kadkade - Marlboro MA, US
Christopher L. Prince - Lansing NY, US
Braden L. Roach - Interlaken NY, US

Phyton Holdings, LLC - San Antonio TX

C12P 17/02

435123

This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known species, e.g., and . Particular modifications of culture conditions (i.e., media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of . Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of is particularly enhanced by use of one or more of these conditions, yield of taxanes for all species has been found to benefit from use of these conditions.

54078164, Apr 18, 1995

Apr 24, 1992

7/874344

Venkataraman Bringi - Ithaca NY
Prakash G. Kadkade - Marlboro MA
Christopher L. Prince - Ithaca NY
Barry F. Schubmehl - Ithaca NY
Eugene J. Kane - Ithaca NY
Braden Roach - Interlaken NY

Phyton Catalytic, Inc. - Ithaca NY

C12P 1702
C12P 1500

435123

This invention is directed to methods for the enhanced production and recovery of taxol and taxanes by cell cultures of Taxus species.

20140093926, Apr 3, 2014

Oct 2, 2013

14/044748

- East Lansing MI, US
- Lansing MI, US
Venkataraman (Bobby) Bringi - Haslett MI, US
Sanchin Jadhav - Lansing MI, US
Dennis Miller - Okemos MI, US
Lars Peereboom - Haslett MI, US
Aspi K. Kolah - Mason MI, US

BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY - East Lansing MI
THE MICHIGAN BIOTECHNOLOGY INSTITUTE - Lansing MI

C12M 1/00
C12P 7/46

435145, 4352891

Crude bio-based organic acid-producing feedstock is used to produce a bio-based organic acid. Related systems and methods are also described such as an integrated method including a step of producing a crude polyol product and then processing the crude polyol product to produce a bio-based organic acid.