Search

Valerian W Nakaar

from Hamden, CT
Age ~67
Get Report
Also known as:
Valerian N Nakaar, Velerian Nakaar, Nakaar Valerian
Phone and address:
338 Hume Dr, New Haven, CT 06514
(203) 230-9283
Connected to:
Haunani H Nakabara, 44Roy H Nakabara, 63Erika Nakabayashi, 40Go Nakabayashi, 45Edgar R Nakache, 68Yoav D Nakache, 39George A Nakad, 67Ghassan F Nakad, 72Joseph A Nakad, 69Akane Nakada, 36

Valerian Nakaar Phones & Addresses

  • 338 Hume Dr, Hamden, CT 06514 (203) 230-9283 (203) 624-9369
  • New Haven, CT
  • Silver Spring, MD
  • Winchester, VA
  • 338 Hume Dr, Hamden, CT 06514 (203) 509-2830

Education

Degree: Associate degree or higher

Resumes

Resumes

Valerian Nakaar Photo 1

Co-Founder, Vice President Research And Development

View page
Location:
338 Hume Dr, Hamden, CT 06514
Industry:
Biotechnology
Work:
Epivax Inc since Mar 2009
Independent Consultant
VaxInnate Corporation Aug 2002 - Feb 2008
Senior Scientist II /Group Leader
Vion Pharmaceuticals May 2000 - May 2002
Senior Research Scientist
Yale University School of Medicine Oct 1997 - May 2000
Associate Research Scientist
Yale University School of Medicine Oct 1992 - Jun 1997
Postdoctoral Fellow/Associate
Education:
Weizmann Institute of Science 1987 - 1992
Ph.D., Molecular and Cell Biology Weizmann Institute of Science 1985 - 1987
M.S., Molecular Biology University of Science & Technology 1979 - 1982
B.S. (Hons), Biological Sciences
Skills:
Biochemistry
Drug Discovery
Molecular Biology
Cell Biology
Lifesciences
Biotechnology
Immunology
Cell
In Vivo
Protein Chemistry
Cell Culture
Clinical Trials
Interests:
Cooking
Exercise
Investing
Traveling
Sweepstakes
Electronics
Home Improvement
Reading
Music
Automobiles
Travel
Movies
Languages:
English
Valerian Nakaar Photo 2

Valerian Nakaar

View page

Business Records

Name / Title
Company / Classification
Phones & Addresses
Valerian Nakaar
CHAIRMAN
FOUNDATION FOR RURAL EDUCATION EMPOWERMENT AND DEVELOPMENT, INC
338 Hume Dr, Hamden, CT 06514
Valerian Nakaar
BEN-NAK EXIM COMPANY, LTD
Exporting
171 County St, New Haven, CT 06511
(203) 782-6622
Valerian Nakaar
Partner
ELITE CONSUMER HUB LLC
10 Cross St, Hamden, CT 06514
338 Hume Dr, Hamden, CT 06514

Publications

Us Patents

Fusion Proteins Comprising Flagellin And Dengue Viral Envelope Proteins

View page
US Patent:
8574588, Nov 5, 2013
Filed:
Jul 18, 2007
Appl. No.:
11/879695
Inventors:
Thomas J. Powell - Madison CT, US
Valerian Nakaar - Hamden CT, US
Langzhou Song - Freehold NJ, US
James W. Huleatt - Nazareth PA, US
William F. McDonald - Madison CT, US
Duane D. Hewitt - Hamilton, CA
Assignee:
VanInnate Corporation - Cranbury NJ
International Classification:
A61K 39/295
US Classification:
4242011
Abstract:
Fusion proteins comprise at least a portion of at least one flagellin and at least a portion of at least one Dengue viral envelope protein. The fusion proteins are used to stimulate an immune response and protective immunity in a subject.

Compositions That Include Hemagglutinin, Methods Of Making And Methods Of Use Thereof

View page
US Patent:
20070224205, Sep 27, 2007
Filed:
Mar 6, 2007
Appl. No.:
11/714684
Inventors:
Thomas Powell - Madison CT, US
Albert Price - New Haven CT, US
Valerian Nakaar - Hamden CT, US
Robert Evans - Souderton PA, US
International Classification:
A61K 39/295
US Classification:
424159100, 424209100, 424201100, 424272100, 424242100
Abstract:
Compositions comprise a flagellin component or a Toll-like Receptor agonist component that is at least a portion of a flagellin or a Toll-like Receptor agonist, wherein the flagellin component or Toll-like Receptor agonist component includes at least one cysteine residue and whereby the flagellin component or Toll-like Receptor agonist component activates a Toll-like Receptor 5 or Toll-like Receptor. Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein at least one lysine of the flagellin component has been substituted with at least one arginine, serine and histidine, whereby the flagellin component activates Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen, a flavivirus antigen, a pathogen-related antigen, a bacterial capsular antigen and a carrier protein. The compositions are used to stimulate an immune response and a protective immune response in a subject.

Compositions That Include Hemagglutinin, Methods Of Making And Methods Of Use Thereof

View page
US Patent:
20070253982, Nov 1, 2007
Filed:
Mar 6, 2007
Appl. No.:
11/714873
Inventors:
Langzhou Song - Freehold NJ, US
Valerian Nakaar - Hamden CT, US
Albert Price - New Haven CT, US
Lynda Tussey - Princeton NJ, US
James Huleatt - Brandford CT, US
Thomas Powell - Madison CT, US
Robert Evans - Souderton PA, US
International Classification:
A61K 39/145
C07H 21/02
C12N 15/86
C07K 14/11
US Classification:
424209100, 435069300, 435456000, 435325000, 530350000, 536023720
Abstract:
Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the protein portion includes at least a portion of a globular head and at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and wherein the protein portion lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions can further include a Toll-like Receptor agonist and a carrier protein.

Novel Polypeptide Ligands For Toll-Like Receptor 2 (Tlr2)

View page
US Patent:
20090028889, Jan 29, 2009
Filed:
Jan 30, 2006
Appl. No.:
11/815092
Inventors:
Valerian Nakaar - Hamden CT, US
Yan Huang - North Branford CT, US
Thomas Powell - Madison CT, US
Assignee:
VAXINNATE CORPORATION - Cranbury NJ
International Classification:
A61K 39/00
C07K 7/00
C12N 5/06
A61P 31/00
US Classification:
4241861, 530330, 4241851, 4241901, 435375
Abstract:
The present invention provides novel polypeptide ligands for Toll-like Receptor 2 (TLR2). Preferrably, the novel polypeptide ligands modulate TLR2 signaling and thereby regulate the Innate Immune Response. The invention also provides vaccines comprising the novel polypeptide TLR2 ligands and an antigen. The invention further provides methods of modulating TLR2 signaling using the polypeptide ligands or vaccines of the invention.

Method To Identify Polypeptide Toll-Like Receptor (Tlr) Ligands

View page
US Patent:
20090068224, Mar 12, 2009
Filed:
Jan 26, 2006
Appl. No.:
11/815095
Inventors:
Valerian Nakaar - Hamden CT, US
Yan Huang - North Branford CT, US
Thomas Powell - Madison CT, US
Assignee:
VAXINNATE CORPORATION - Cranbury NJ
International Classification:
A61K 39/12
C40B 10/00
C40B 30/04
C07K 2/00
A61K 39/00
A61P 35/00
A61P 37/08
A61P 31/12
A61K 38/02
C12N 5/06
A61K 39/145
US Classification:
4242091, 506 1, 506 9, 530350, 514 2, 435375, 4241841, 4242771, 4242751, 4242181, 4242041
Abstract:
The present invention provides novel methods to identify polypeptide ligands for Toll-like Receptors (TLRs), such as TLR2, TLR4 and TLR5. The method involves the use of phage display technology in an iterative biopanning procedure. The invention also provides polypeptide TLR ligands identified by the methods of the invention. In preferred embodiments, the polypeptide TLR ligands so identified modulate TLR signaling and thereby regulate the Innate Immune Response. The invention also provides vaccines comprising a polypeptide TLR ligand identified by the methods of the invention and an antigen. The invention also provides methods of modulating TLR signaling using the polypeptide TLR ligands and vaccines of the invention.

Compositions Of Influenza Viral Proteins And Methods Of Use Thereof

View page
US Patent:
20090162400, Jun 25, 2009
Filed:
Jun 18, 2007
Appl. No.:
11/820148
Inventors:
Thomas J. Powell - Madison CT, US
James W. Huleatt - Nazareth PA, US
Valerian Nakaar - Hamden CT, US
Langzhou Song - Freehold NJ, US
William F. McDonald - Madison CT, US
Albert E. Price - New Haven CT, US
Duane D. Hewitt - Hamilton, CA
International Classification:
A61K 39/145
A61P 37/04
US Classification:
4242101
Abstract:
Compositions, fusion proteins and polypeptides comprise at least one pathogen-associated molecular pattern and at least a portion of at least one integral membrane protein of an influenza viral antigen. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject.

Compositions Of Toll-Like Receptor Agonists And Papillomavirus Antigens And Methods Of Use Thereof

View page
US Patent:
20100303847, Dec 2, 2010
Filed:
May 26, 2010
Appl. No.:
12/787649
Inventors:
Valerian Nakaar - Hamden CT, US
James W. Huleatt - Nazareth PA, US
Thomas J. Powell - Madison CT, US
Albert E. Price - New Haven CT, US
International Classification:
A61K 39/12
A61P 37/04
US Classification:
4241861
Abstract:
Compositions that include at least one protein that activates a Toll-like Receptor and includes at least a portion of at least one Toll-like Receptor agonist and at least a portion of at least one papillomavirus suppressor binding protein, papillomavirus transforming protein and papillomavirus capsid protein can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can further include an adjuvant and a carrier protein.

Compositions Of Toll-Like Receptor Agonists And Malaria Antigens And Methods Of Use

View page
US Patent:
20110008383, Jan 13, 2011
Filed:
Jun 14, 2010
Appl. No.:
12/814945
Inventors:
THOMAS J. POWELL - MADISON CT, US
VALERIAN NAKAAR - HAMDEN CT, US
WILLIAM F. MCDONALD - MADISON CT, US
ELIZABETH H. NARDIN - LEONIA NJ, US
International Classification:
A61K 39/015
A61P 37/04
A61P 33/06
US Classification:
4241921
Abstract:
Compositions that include at least one fusion protein that includes at least a portion of at least one flagellin and at least a portion of at least one malaria antigen can be employed in methods that stimulate an immune response in a subject, in particular, sterile immunity and a protective immune response in a subject.
Control profile
Valerian W Nakaar from Hamden, CT, age ~67 Get Report