Petros Dr Tsipouras

6759663, Jul 6, 2004

Jul 22, 2002

10/182210

Petros Tsipouras - Madison CT
Triantafyllos Tafas - Rocky Hill CT

Ikonisys, Inc. - New Haven CT

G01N 2164

2504581, 385 12

The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.

6956695, Oct 18, 2005

Mar 19, 2002

10/102500

Triantafyllos Tafas - Rocky Hill CT, US
Petros Tsipouras - Madison CT, US

Ikonisys, Inc. - New Haven CT

G02B021/34

359396, 356244

The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.

7196788, Mar 27, 2007

Jun 15, 2004

10/868712

Petros Tsipouras - Madison CT, US

Ikonisys, Inc. - New Haven CT

G01N 21/64

356317, 2504581, 385 12

The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.

7330309, Feb 12, 2008

Sep 13, 2005

11/225460

Triantafyllos Tafas - Rocky Hill CT, US
Petros Tsipouras - Madison CT, US

Ikonisys, Inc. - New Haven CT

G02B 21/34

359396, 359359

The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.

7346200, Mar 18, 2008

Nov 18, 1999

10/130559

Petros Tsipouras - Madison CT, US
Triantafyllos P. Tafas - Rocky Hill CT, US

Ikonisys, Inc. - New Haven CT

G06K 9/00

382128, 382133, 382134

A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

7471079, Dec 30, 2008

Aug 2, 2007

11/833203

Triantafyllos Tafas - Rocky Hill CT, US
Yash Agarwal - New Haven CT, US
Youngmin Kim - Wallingford CT, US
Wei Guo - Unionville CT, US
Richard Eberle - Wolcott CT, US
Joseph Turgeon - Killingworth CT, US
Michael Kilpatrick - West Hartford CT, US
Petros Tsipouras - Madison CT, US

Ikonisys, Inc. - New Haven CT

G01R 31/302

3241581, 324750, 324752

A light-tight enclosure system, displaceable along a surface, for housing an automated microscope, having electronically controllable components and an image capturing device. The enclosure system may include device for displacement, a shelf for placement of the automated microscope, an externally viewable monitor, and a plurality of electrical power receptacles.

7477820, Jan 13, 2009

Mar 27, 2007

11/691989

Petros Tsipouras - Madison CT, US
Triantafyllos P. Tafas - Rocky Hill CT, US

Ikonisys, Inc. - New Haven CT

G02B 6/02

385123

The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.

7522757, Apr 21, 2009

Nov 1, 2005

11/264273

Petros Tsipouras - Madison CT, US
Triantafyllos Tafas - Rocky Hill CT, US

Ikonisys, Inc. - New Haven CT

G06K 9/00

382133, 382134, 382128

A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.